Tanja Taivassalo,
RES ASO PROF
Department:
Department of Physiology and Aging
Business Phone:
(352) 339-6666
Business Email:
ttaivassalo@ufl.edu
Teaching Profile
Courses Taught
2020-2023
PAS5025 Human Physiology
2020-2024
GMS6440 Fundamentals of Medical Physiology
2020-2021
GMS5905 Special Topics in Biomedical Sciences
2017-2019
APK4120 Clinical Exercise Physiology
2017
PET5936 Special Topics/Seminars
2020-2022,2024
BMS3521 Human Physiology in Translation
2022-2024
GMS6740 Neuromuscular Diseases
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0001-8923-2921
Publications
2024
Resting-state Functional Connectivity of the Motor and Cognitive Areas is Preserved in Masters Athletes.
Neuroscience.
546:53-62
[DOI] 10.1016/j.neuroscience.2024.03.024.
[PMID] 38522662.
2023
OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases.
Communications biology.
6(1)
[DOI] 10.1038/s42003-022-04303-x.
[PMID] 36635485.
2022
Chronic aryl hydrocarbon receptor activity phenocopies smoking-induced skeletal muscle impairment.
Journal of cachexia, sarcopenia and muscle.
13(1):589-604
[DOI] 10.1002/jcsm.12826.
[PMID] 34725955.
2022
Commentaries on Viewpoint: Hoping for the best, prepared for the worst: can we perform remote data collection in sport sciences?
Journal of applied physiology (Bethesda, Md. : 1985).
133(6):1433-1440
[DOI] 10.1152/japplphysiol.00613.2022.
[PMID] 36509417.
2022
Integrating Mechanisms of Exacerbated Atrophy and Other Adverse Skeletal Muscle Impact in COPD.
Frontiers in physiology.
13
[DOI] 10.3389/fphys.2022.861617.
[PMID] 35721564.
2022
Unbiased proteomics, histochemistry, and mitochondrial DNA copy number reveal better mitochondrial health in muscle of high-functioning octogenarians.
eLife.
11
[DOI] 10.7554/eLife.74335.
[PMID] 35404238.
2021
Postcontractile blood oxygenation level-dependent (BOLD) response in Duchenne muscular dystrophy.
Journal of applied physiology (Bethesda, Md. : 1985).
131(1):83-94
[DOI] 10.1152/japplphysiol.00634.2020.
[PMID] 34013753.
2021
Safety, feasibility, and efficacy of strengthening exercise in Duchenne muscular dystrophy.
Muscle & nerve.
63(3):320-326
[DOI] 10.1002/mus.27137.
[PMID] 33295018.
2021
Walking activity in a large cohort of boys with Duchenne muscular dystrophy.
Muscle & nerve.
63(2):192-198
[DOI] 10.1002/mus.27119.
[PMID] 33188573.
2019
Fidelity of muscle fibre reinnervation modulates ageing muscle impact in elderly women.
The Journal of physiology.
597(19):5009-5023
[DOI] 10.1113/JP278261.
[PMID] 31368533.
2017
Common data elements for clinical research in mitochondrial disease: a National Institute for Neurological Disorders and Stroke project.
Journal of inherited metabolic disease.
40(3):403-414
[DOI] 10.1007/s10545-017-0035-5.
[PMID] 28303425.
2017
Eccentric Ergometer Training Promotes Locomotor Muscle Strength but Not Mitochondrial Adaptation in Patients with Severe Chronic Obstructive Pulmonary Disease.
Frontiers in physiology.
8
[DOI] 10.3389/fphys.2017.00114.
[PMID] 28316572.
2017
Eccentric Exercise and the Critically Ill Patient.
Frontiers in physiology.
8
[DOI] 10.3389/fphys.2017.00120.
[PMID] 28293200.
2016
Addressing Assumptions for the Use of Non-invasive Cardiac Output Measurement Techniques During Exercise in COPD.
COPD.
13(1):75-81
[DOI] 10.3109/15412555.2015.1043985.
[PMID] 26408087.
2016
Contribution of the Mitochondria to Locomotor Muscle Dysfunction in Patients With COPD.
Chest.
149(5):1302-12
[DOI] 10.1016/j.chest.2015.11.021.
[PMID] 26836890.
2016
Denervation drives mitochondrial dysfunction in skeletal muscle of octogenarians.
The Journal of physiology.
594(24):7361-7379
[DOI] 10.1113/JP272487.
[PMID] 27619626.
2016
Failed upregulation of TFAM protein and mitochondrial DNA in oxidatively deficient fibers of chronic obstructive pulmonary disease locomotor muscle.
Skeletal muscle.
6
[DOI] 10.1186/s13395-016-0083-9.
[PMID] 26893822.
2016
Lung Function and Bronchial Hyperresponsiveness in Adults Born Prematurely. A Cohort Study.
Annals of the American Thoracic Society.
13(1):17-24
[DOI] 10.1513/AnnalsATS.201508-553OC.
[PMID] 26523350.
2016
Motor unit number and transmission stability in octogenarian world class athletes: Can age-related deficits be outrun?
Journal of applied physiology (Bethesda, Md. : 1985).
121(4):1013-1020
[DOI] 10.1152/japplphysiol.00149.2016.
[PMID] 27013605.
2016
Reduction in single muscle fiber rate of force development with aging is not attenuated in world class older masters athletes.
American journal of physiology. Cell physiology.
310(4):C318-27
[DOI] 10.1152/ajpcell.00289.2015.
[PMID] 26632598.
2015
Anthracycline-containing chemotherapy causes long-term impairment of mitochondrial respiration and increased reactive oxygen species release in skeletal muscle.
Scientific reports.
5
[DOI] 10.1038/srep08717.
[PMID] 25732599.
2015
Lactate and Energy Metabolism During Exercise in Patients With Blocked Glycogenolysis (McArdle Disease).
The Journal of clinical endocrinology and metabolism.
100(8):E1096-104
[DOI] 10.1210/jc.2015-1339.
[PMID] 26030324.
2014
An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine.
189(9):e15-62
[DOI] 10.1164/rccm.201402-0373ST.
[PMID] 24787074.
2014
Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
28(4):1621-33
[DOI] 10.1096/fj.13-242750.
[PMID] 24371120.
2014
Physiological mechanisms of sex differences in exertional dyspnoea: role of neural respiratory motor drive.
Experimental physiology.
99(2):427-41
[DOI] 10.1113/expphysiol.2013.074880.
[PMID] 24213856.
2014
The relationship between muscle fiber type-specific PGC-1α content and mitochondrial content varies between rodent models and humans.
PloS one.
9(8)
[DOI] 10.1371/journal.pone.0103044.
[PMID] 25121500.
2013
Autophagy in locomotor muscles of patients with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine.
188(11):1313-20
[DOI] 10.1164/rccm.201304-0732OC.
[PMID] 24228729.
2012
Cytochrome c oxidase-intermediate fibres: importance in understanding the pathogenesis and treatment of mitochondrial myopathy.
Neuromuscular disorders : NMD.
22(8):690-8
[DOI] 10.1016/j.nmd.2012.04.003.
[PMID] 22647770.
2012
Increased capillaries in mitochondrial myopathy: implications for the regulation of oxygen delivery.
Brain : a journal of neurology.
135(Pt 1):53-61
[DOI] 10.1093/brain/awr293.
[PMID] 22232594.
2012
Mitochondrial dysfunction and lipid accumulation in the human diaphragm during mechanical ventilation.
American journal of respiratory and critical care medicine.
186(11):1140-9
[DOI] 10.1164/rccm.201206-0982OC.
[PMID] 23024021.
2011
Altered mitochondrial regulation in quadriceps muscles of patients with COPD.
Clinical physiology and functional imaging.
31(2):124-31
[DOI] 10.1111/j.1475-097X.2010.00988.x.
[PMID] 21091605.
2011
Eccentric cycle exercise in severe COPD: feasibility of application.
COPD.
8(4):270-4
[DOI] 10.3109/15412555.2011.579926.
[PMID] 21728805.
2011
Exertional dyspnea in mitochondrial myopathy: clinical features and physiological mechanisms.
American journal of physiology. Regulatory, integrative and comparative physiology.
301(4):R873-84
[DOI] 10.1152/ajpregu.00001.2011.
[PMID] 21813873.
2011
Mitochondria: isolation, structure and function.
The Journal of physiology.
589(Pt 18):4413-21
[DOI] 10.1113/jphysiol.2011.212712.
[PMID] 21708903.
2011
Mitochondrial structure and function are disrupted by standard isolation methods.
PloS one.
6(3)
[DOI] 10.1371/journal.pone.0018317.
[PMID] 21512578.
2010
Mitochondrial functional impairment with aging is exaggerated in isolated mitochondria compared to permeabilized myofibers.
Aging cell.
9(6):1032-46
[DOI] 10.1111/j.1474-9726.2010.00628.x.
[PMID] 20849523.
2009
Effect of changes in fat availability on exercise capacity in McArdle disease.
Archives of neurology.
66(6):762-6
[DOI] 10.1001/archneurol.2009.93.
[PMID] 19506137.
2009
Fat metabolism during exercise in patients with McArdle disease.
Neurology.
72(8):718-24
[DOI] 10.1212/01.wnl.0000343002.74480.e4.
[PMID] 19237700.
2008
A homoplasmic mtDNA variant can influence the phenotype of the pathogenic m.7472Cins MTTS1 mutation: are two mutations better than one?
European journal of human genetics : EJHG.
16(10):1265-74
[DOI] 10.1038/ejhg.2008.65.
[PMID] 18398437.
2008
Resistance training in patients with single, large-scale deletions of mitochondrial DNA.
Brain : a journal of neurology.
131(Pt 11):2832-40
[DOI] 10.1093/brain/awn252.
[PMID] 18984605.
2008
Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance.
American journal of human genetics.
82(3):652-60
[DOI] 10.1016/j.ajhg.2007.12.012.
[PMID] 18304497.
2008
The mitochondrial phenotype of peripheral muscle in chronic obstructive pulmonary disease: disuse or dysfunction?
American journal of respiratory and critical care medicine.
178(10):1040-7
[DOI] 10.1164/rccm.200807-1005OC.
[PMID] 18755922.
2007
The effect of training on the expression of mitochondrial biogenesis- and apoptosis-related proteins in skeletal muscle of patients with mtDNA defects.
American journal of physiology. Endocrinology and metabolism.
293(3):E672-80
[PMID] 17551003.
2006
Aerobic conditioning: an effective therapy in McArdle’s disease.
Annals of neurology.
59(6):922-8
[PMID] 16718692.
2006
Endurance training and detraining in mitochondrial myopathies due to single large-scale mtDNA deletions.
Brain : a journal of neurology.
129(Pt 12):3391-401
[PMID] 17085458.
2005
Exercise and training in mitochondrial myopathies.
Medicine and science in sports and exercise.
37(12):2094-101
[PMID] 16331135.
2004
Implications of exercise training in mtDNA defects–use it or lose it?
Biochimica et biophysica acta.
1659(2-3):221-31
[PMID] 15576055.
2003
Identification and characterization of a common set of complex I assembly intermediates in mitochondria from patients with complex I deficiency.
The Journal of biological chemistry.
278(44):43081-8
[PMID] 12941961.
2003
The spectrum of exercise tolerance in mitochondrial myopathies: a study of 40 patients.
Brain : a journal of neurology.
126(Pt 2):413-23
[PMID] 12538407.
2002
Venous oxygen levels during aerobic forearm exercise: An index of impaired oxidative metabolism in mitochondrial myopathy.
Annals of neurology.
51(1):38-44
[PMID] 11782982.
2000
Muscle phosphorus magnetic resonance spectroscopy oxidative indices correlate with physical activity.
Muscle & nerve.
23(2):175-81
[PMID] 10639607.
2000
Muscle responses to exercise in health and disease.
Neurologic clinics.
18(1):15-34
[PMID] 10658167.
2000
Recurrent myoglobinuria due to a nonsense mutation in the COX I gene of mitochondrial DNA.
Neurology.
55(5):644-9
[PMID] 10980727.
1999
Gene shifting: a novel therapy for mitochondrial myopathy.
Human molecular genetics.
8(6):1047-52
[PMID] 10332036.
1999
Short-term aerobic training response in chronic myopathies.
Muscle & nerve.
22(9):1239-43
[PMID] 10454720.
1998
Effects of aerobic training in patients with mitochondrial myopathies.
Neurology.
50(4):1055-60
[PMID] 9566394.
1998
Intracellular phosphates in inclusion body myositis–a 31P magnetic resonance spectroscopy study.
Muscle & nerve.
21(11):1523-5
[PMID] 9771678.
1997
Abnormal oxidative metabolism in exercise intolerance of undetermined origin.
Neuromuscular disorders : NMD.
7(2):99-104
[PMID] 9131650.
1997
Applications of magnetic resonance spectroscopy to diagnosis and monitoring of mitochondrial disease.
Italian journal of neurological sciences.
18(6):341-51
[PMID] 9494866.
1996
Combined aerobic training and dichloroacetate improve exercise capacity and indices of aerobic metabolism in muscle cytochrome oxidase deficiency.
Neurology.
47(2):529-34
[PMID] 8757032.
Grants
Sep 2023
ACTIVE
Countering sympathetic vasoconstriction during skeletal muscle exercise as an adjuvant therapy for DMD
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
Sep 2022
ACTIVE
Functional electrical stimulation (FES) cycling training to improve motor and cardiac functions in patients with Friedreichs Ataxia: a feasibility and efficacy study
Role: Co-Investigator
Funding: FRIEDREICHS ATAXIA RESEARCH ALLIANCE
Sep 2021
– Aug 2023
Measuring cardiopulmonary responses to the 6MWT and peak effort exercise in DMD
Role: Principal Investigator
Funding: MUSCULAR DYSTROPHY ASSO
Mar 2021
ACTIVE
CTOA
Role: Principal Investigator
Funding: UNIV OF FLORIDA
Jan 2020
ACTIVE
Use of a biomarker approach to optimize rehabilitation strategies for DMD patients
Role: Principal Investigator
Funding: EDGEWISE THERAPEUTICS
Jul 2019
ACTIVE
Impact and Interplay of Corticosteroid Regimen and Exercise Training on DMD Muscle Function
Role: Principal Investigator
Funding: US ARMY MED RES ACQUISITION
Apr 2017
– Jun 2021
OoR CTSI Institutional Matching Support
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Contact Details
Phones:
- Business:
- (352) 339-6666
Emails:
- Business:
- ttaivassalo@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100274
GAINESVILLE FL 32610