Karyn Esser,
Professor And Chair
Department:
Department of Physiology and Aging
Business Phone:
(352) 273-5728
Business Email:
kaesser@ufl.edu
About Karyn Esser
My lab has pioneered research on the role of circadian rhythms and the molecular clock mechanism in skeletal muscle homeostasis and health. Using genetic mouse models, we found that mutations of two different molecular clock genes, Clock and Bmal1, dramatically disrupt skeletal muscle structure and function. The lab is also pursuing the role of physical activity/exercise as a time cue for skeletal muscle and other tissues. We have also shown that time of exercise can significantly alter the clock mechanism in skeletal muscle independent of lighting and the central clock in the brain. Our research goals are to define the transcriptional networks and downstream mechanisms that link the molecular clock with proper skeletal muscle function and phenotype. Additionally we are working in mouse and human models to determine the potential for time of day lifestyle interventions as a therapeutic approach to enhance molecular clock function and attenuate conditions of muscle weakness and wasting seen with aging and chronic diseases.
Additional Positions:
Co-Director, UF Pepper Center
2022 – Current
·
Teaching Profile
Courses Taught
2019-2024
GMS6476 Fundamentals of Skeletal Muscle
2019-2020
GMS6473 Fundamentals of Physiology and Functional Genomics III
2018
GMS7593 Topics in Pharmacology and Toxicology
2018
GMS7979 Advanced Research
2018
GMS7980 Research for Doctoral Dissertation
2018
GMS7794 Neuroscience Seminar
2020-2022
BMS3521 Human Physiology in Translation
2021-2024
GMS6495 Seminar in Physiology
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-5791-1441
Publications
2023
Defining the age-dependent and tissue-specific circadian transcriptome in male mice
Cell Reports.
42(1)
[DOI] 10.1016/j.celrep.2022.111982.
[PMID] 36640301.
2023
Early morning run-training results in enhanced endurance performance adaptations in mice.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.09.18.557933.
[PMID] 37781623.
2023
Editorial: Circadian rhythms and exercise in cardiometabolic health.
Frontiers in endocrinology.
14
[DOI] 10.3389/fendo.2023.1180851.
[PMID] 37025402.
2023
Experimental design and power calculation in omics circadian rhythmicity detection using the cosinor model.
Statistics in medicine.
42(18):3236-3258
[DOI] 10.1002/sim.9803.
[PMID] 37265194.
2023
Inflammation o’clock: interactions of circadian rhythms with inflammation‐induced skeletal muscle atrophy
The Journal of Physiology.
[DOI] 10.1113/jp284808.
2023
Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions
Physiological Reviews.
103(4):2679-2757
[DOI] 10.1152/physrev.00039.2022.
[PMID] 37382939.
2023
Metabolism and exercise: the skeletal muscle clock takes centre stage
Nature Reviews Endocrinology.
19(5):272-284
[DOI] 10.1038/s41574-023-00805-8.
2023
Multi-omic identification of key transcriptional regulatory programs during endurance exercise training.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.01.10.523450.
[PMID] 36711841.
2023
Muscle Bmal1 is necessary for normal transcriptomic and metabolomic adaptation to endurance exercise training.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.10.13.562100.
[PMID] 37905004.
2023
The Study of Muscle, Mobility and Aging (SOMMA): A Unique Cohort Study About the Cellular Biology of Aging and Age-related Loss of Mobility.
The journals of gerontology. Series A, Biological sciences and medical sciences.
78(11):2083-2093
[DOI] 10.1093/gerona/glad052.
[PMID] 36754371.
2023
Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary.
GeroScience.
45(1):569-589
[DOI] 10.1007/s11357-022-00668-3.
[PMID] 36242693.
2022
A wrinkle in time: circadian biology in pulmonary vascular health and disease
American Journal of Physiology-Lung Cellular and Molecular Physiology.
322(1):L84-L101
[DOI] 10.1152/ajplung.00037.2021.
[PMID] 34850650.
2022
Apparent Absence of BMAL1-Dependent Skeletal Muscle-Kidney Cross Talk in Mice.
Biomolecules.
12(2)
[DOI] 10.3390/biom12020261.
[PMID] 35204763.
2022
Author response: The skeletal muscle circadian clock regulates titin splicing through RBM20
.
[DOI] 10.7554/elife.76478.sa2.
2022
Optimization of the Omni-ATAC protocol to chromatin accessibility profiling in snap-frozen rat adipose and muscle tissues
MethodsX.
9
[DOI] 10.1016/j.mex.2022.101681.
[PMID] 35464805.
2022
Reuniting the Body “Neck Up and Neck Down” to Understand Cognitive Aging: The Nexus of Geroscience and Neuroscience.
The journals of gerontology. Series A, Biological sciences and medical sciences.
77(1):e1-e9
[DOI] 10.1093/gerona/glab215.
[PMID] 34309630.
2022
The circadian E3 ligase FBXL21 regulates myoblast differentiation and sarcomere architecture via MYOZ1 ubiquitination and NFAT signaling.
PLoS genetics.
18(12)
[DOI] 10.1371/journal.pgen.1010574.
[PMID] 36574402.
2022
The role of the cardiomyocyte circadian clocks in ion channel regulation and cardiac electrophysiology
The Journal of Physiology.
600(9):2037-2048
[DOI] 10.1113/jp282402.
2022
The skeletal muscle circadian clock regulates titin splicing through RBM20
eLife.
11
[DOI] 10.7554/elife.76478.
2022
Time for Exercise? Exercise and Its Influence on the Skeletal Muscle Clock.
Journal of biological rhythms.
37(6):579-592
[DOI] 10.1177/07487304221122662.
[PMID] 36129164.
2022
Timing of food intake in mice unmasks a role for the cardiomyocyte circadian clock mechanism in limiting QT-interval prolongation
Chronobiology International.
39(4):525-534
[DOI] 10.1080/07420528.2021.2011307.
[PMID] 34875962.
2021
A Role for Exercise to Counter Skeletal Muscle Clock Disruption.
Exercise and sport sciences reviews.
49(1):35-41
[DOI] 10.1249/JES.0000000000000235.
[PMID] 33044328.
2021
Binge alcohol disrupts skeletal muscle core molecular clock independent of glucocorticoids
American Journal of Physiology-Endocrinology and Metabolism.
321(5):E606-E620
[DOI] 10.1152/ajpendo.00187.2021.
[PMID] 34541876.
2021
Cardiomyocyte Deletion of Bmal1 Exacerbates QT- and RR-Interval Prolongation in Scn5a +/ΔKPQ Mice.
Frontiers in physiology.
12
[DOI] 10.3389/fphys.2021.681011.
[PMID] 34248669.
2021
Circadian Rhythm Effects on the Molecular Regulation of Physiological Systems.
Comprehensive Physiology.
12(1):2769-2798
[DOI] 10.1002/cphy.c210011.
[PMID] 34964116.
2021
Differential analysis of chromatin accessibility and gene expression profiles identifies cis-regulatory elements in rat adipose and muscle.
Genomics.
113(6):3827-3841
[DOI] 10.1016/j.ygeno.2021.09.013.
[PMID] 34547403.
2021
Disrupted circadian oscillations in type 2 diabetes are linked to altered rhythmic mitochondrial metabolism in skeletal muscle
Science Advances.
7(43)
[DOI] 10.1126/sciadv.abi9654.
[PMID] 34669477.
2021
Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms.
Molecular metabolism.
43
[DOI] 10.1016/j.molmet.2020.101110.
[PMID] 33137489.
2021
Faculty Opinions recommendation of Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.
[DOI] 10.3410/f.722672758.793589391.
2021
Integrated multiomics analysis identifies molecular landscape perturbations during hyperammonemia in skeletal muscle and myotubes.
The Journal of biological chemistry.
297(3)
[DOI] 10.1016/j.jbc.2021.101023.
[PMID] 34343564.
2021
Likelihood-based tests for detecting circadian rhythmicity and differential circadian patterns in transcriptomic applications.
Briefings in bioinformatics.
22(6)
[DOI] 10.1093/bib/bbab224.
[PMID] 34117739.
2021
Time of Day and Muscle Strength: A Circadian Output?
Physiology.
36(1):44-51
[DOI] 10.1152/physiol.00030.2020.
[PMID] 33325817.
2020
Circadian clock genes and respiratory neuroplasticity genes oscillate in the phrenic motor system
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.
318(6):R1058-R1067
[DOI] 10.1152/ajpregu.00010.2020.
[PMID] 32348679.
2020
Exercise sets the muscle clock with a calcium assist
The Journal of Physiology.
598(24):5591-5592
[DOI] 10.1113/jp280783.
2020
Exercise sets the muscle clock with a calcium assist
The Journal of Physiology.
598(24):5591-5592
[DOI] 10.1113/jp280783.
2020
Innovations in Geroscience to enhance mobility in older adults.
Experimental gerontology.
142
[DOI] 10.1016/j.exger.2020.111123.
[PMID] 33191210.
2020
Longitudinal Characterization and Biomarkers of Age and Sex Differences in the Decline of Spatial Memory.
Frontiers in aging neuroscience.
12
[DOI] 10.3389/fnagi.2020.00034.
[PMID] 32153384.
2020
Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging.
Frontiers in physiology.
11
[DOI] 10.3389/fphys.2020.00963.
[PMID] 32903666.
2020
Relationship Between Nicotine Intake and Reward Function in Rats With Intermittent Short Versus Long Access to Nicotine.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.
22(2):213-223
[DOI] 10.1093/ntr/ntz052.
[PMID] 30958557.
2020
The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function
Cell Reports.
32(11)
[DOI] 10.1016/j.celrep.2020.108140.
[PMID] 32937135.
2020
Ticking for Metabolic Health: The Skeletal‐Muscle Clocks
Obesity.
28(S1)
[DOI] 10.1002/oby.22826.
[PMID] 32468732.
2020
Time‐of‐day dependent effects of contractile activity on the phase of the skeletal muscle clock
The Journal of Physiology.
598(17):3631-3644
[DOI] 10.1113/jp279779.
2020
Time‐of‐day dependent effects of contractile activity on the phase of the skeletal muscle clock
The Journal of Physiology.
598(17):3631-3644
[DOI] 10.1113/jp279779.
2019
Author response: Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model
.
[DOI] 10.7554/elife.49920.024.
2019
Author response: MYOD1 functions as a clock amplifier as well as a critical co-factor for downstream circadian gene expression in muscle
.
[DOI] 10.7554/elife.43017.026.
2019
Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model
eLife.
8
[DOI] 10.7554/elife.49920.
2019
Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model
eLife.
8
[DOI] 10.7554/elife.49920.
2019
Culturing C2C12 myotubes on micromolded gelatin hydrogels accelerates myotube maturation.
Skeletal muscle.
9(1)
[DOI] 10.1186/s13395-019-0203-4.
[PMID] 31174599.
2019
Disruptions to the limb muscle core molecular clock coincide with changes in mitochondrial quality control following androgen depletion
American Journal of Physiology-Endocrinology and Metabolism.
317(4):E631-E645
[DOI] 10.1152/ajpendo.00177.2019.
[PMID] 31361545.
2019
Exercise Timing and Circadian Rhythms.
Current opinion in physiology.
10:64-69
[DOI] 10.1016/j.cophys.2019.04.020.
[PMID] 31938759.
2019
Impaired Ribosomal Biogenesis by Noncanonical Degradation of β-Catenin during Hyperammonemia.
Molecular and cellular biology.
39(16)
[DOI] 10.1128/MCB.00451-18.
[PMID] 31138664.
2019
MYOD1 functions as a clock amplifier as well as a critical co-factor for downstream circadian gene expression in muscle
eLife.
8
[DOI] 10.7554/elife.43017.
2019
MYOD1 functions as a clock amplifier as well as a critical co-factor for downstream circadian gene expression in muscle
eLife.
8
[DOI] 10.7554/elife.43017.
2019
Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge
Nature Communications.
10(1)
[DOI] 10.1038/s41467-019-11926-y.
[PMID] 31462679.
2018
Author response: Transcriptional profiling reveals extraordinary diversity among skeletal muscle tissues
.
[DOI] 10.7554/elife.34613.040.
2018
Lipin-1 regulates Bnip3-mediated mitophagy in glycolytic muscle.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
32(12):6796-6807
[DOI] 10.1096/fj.201800374.
[PMID] 29939786.
2018
Reinventing the wheel: comparison of two wheel cage styles for assessing mouse voluntary running activity.
Journal of applied physiology (Bethesda, Md. : 1985).
124(4):923-929
[DOI] 10.1152/japplphysiol.00880.2017.
[PMID] 29357507.
2018
Transcriptional profiling reveals extraordinary diversity among skeletal muscle tissues
eLife.
7
[DOI] 10.7554/elife.34613.
2018
Transcriptional profiling reveals extraordinary diversity among skeletal muscle tissues
eLife.
7
[DOI] 10.7554/elife.34613.
2017
Author response: Bmal1 function in skeletal muscle regulates sleep
.
[DOI] 10.7554/elife.26557.014.
2017
Bmal1 function in skeletal muscle regulates sleep
eLife.
6
[DOI] 10.7554/elife.26557.
2017
Bmal1 function in skeletal muscle regulates sleep
eLife.
6
[DOI] 10.7554/elife.26557.
2017
Guidelines for Genome-Scale Analysis of Biological Rhythms.
Journal of biological rhythms.
32(5):380-393
[DOI] 10.1177/0748730417728663.
[PMID] 29098954.
2017
Homeostatic effects of exercise and sleep on metabolic processes in mice with an overexpressed skeletal muscle clock.
Biochimie.
132:161-165
[DOI] 10.1016/j.biochi.2016.11.014.
[PMID] 27916643.
2017
The Role of the Molecular Clock in Skeletal Muscle and What It Is Teaching Us About Muscle-Bone Crosstalk.
Current osteoporosis reports.
15(3):222-230
[DOI] 10.1007/s11914-017-0363-2.
[PMID] 28421465.
2016
Deep RNA profiling identified CLOCK and molecular clock genes as pathophysiological signatures in collagen VI myopathy.
Journal of cell science.
129(8):1671-84
[DOI] 10.1242/jcs.175927.
[PMID] 26945058.
2016
Muscle-specific loss of Bmal1 leads to disrupted tissue glucose metabolism and systemic glucose homeostasis.
Skeletal muscle.
6
[DOI] 10.1186/s13395-016-0082-x.
[PMID] 27486508.
2016
Reply from Elizabeth Schroder, Brian Hodge, Lance Riley, Xiping Zhang and Karyn Esser.
The Journal of physiology.
594(11):3163-4
[DOI] 10.1113/JP272165.
[PMID] 27246552.
2015
A prospective analysis of factors associated with decreased physical activity in patients with cirrhosis undergoing transplant evaluation.
Clinical transplantation.
29(11):958-64
[DOI] 10.1111/ctr.12602.
[PMID] 26263921.
2015
Blunted hypertrophic response in aged skeletal muscle is associated with decreased ribosome biogenesis.
Journal of applied physiology (Bethesda, Md. : 1985).
119(4):321-7
[DOI] 10.1152/japplphysiol.00296.2015.
[PMID] 26048973.
2015
Circadian rhythms, the molecular clock, and skeletal muscle.
Journal of biological rhythms.
30(2):84-94
[DOI] 10.1177/0748730414561638.
[PMID] 25512305.
2015
Identification of a conserved set of upregulated genes in mouse skeletal muscle hypertrophy and regrowth.
Journal of applied physiology (Bethesda, Md. : 1985).
118(1):86-97
[DOI] 10.1152/japplphysiol.00351.2014.
[PMID] 25554798.
2015
Intrinsic muscle clock is necessary for musculoskeletal health.
The Journal of physiology.
593(24):5387-404
[DOI] 10.1113/JP271436.
[PMID] 26486627.
2015
Lipin1 Regulates Skeletal Muscle Differentiation through Extracellular Signal-regulated Kinase (ERK) Activation and Cyclin D Complex-regulated Cell Cycle Withdrawal.
The Journal of biological chemistry.
290(39):23646-55
[DOI] 10.1074/jbc.M115.686519.
[PMID] 26296887.
2015
Physical activity, and not fat mass is a primary predictor of circadian parameters in young men.
Chronobiology international.
32(6):832-41
[DOI] 10.3109/07420528.2015.1043011.
[PMID] 26101893.
2015
Smooth-muscle BMAL1 participates in blood pressure circadian rhythm regulation.
The Journal of clinical investigation.
125(1):324-36
[DOI] 10.1172/JCI76881.
[PMID] 25485682.
2015
The cardiomyocyte molecular clock regulates the circadian expression of Kcnh2 and contributes to ventricular repolarization.
Heart rhythm.
12(6):1306-14
[DOI] 10.1016/j.hrthm.2015.02.019.
[PMID] 25701773.
2015
The endogenous molecular clock orchestrates the temporal separation of substrate metabolism in skeletal muscle.
Skeletal muscle.
5
[DOI] 10.1186/s13395-015-0039-5.
[PMID] 26000164.
2014
Light phase-restricted feeding slows basal heart rate to exaggerate the type-3 long QT syndrome phenotype in mice.
American journal of physiology. Heart and circulatory physiology.
307(12):H1777-85
[DOI] 10.1152/ajpheart.00341.2014.
[PMID] 25343952.
2014
Targeting the Wnt/β-catenin signaling pathway in liver cancer stem cells and hepatocellular carcinoma cell lines with FH535.
PloS one.
9(6)
[DOI] 10.1371/journal.pone.0099272.
[PMID] 24940873.
2013
Automated image segmentation of haematoxylin and eosin stained skeletal muscle cross-sections.
Journal of microscopy.
252(3):275-85
[DOI] 10.1111/jmi.12090.
[PMID] 24118017.
2013
Chronic phase advance alters circadian physiological rhythms and peripheral molecular clocks.
Journal of applied physiology (Bethesda, Md. : 1985).
115(3):373-82
[DOI] 10.1152/japplphysiol.01139.2012.
[PMID] 23703115.
2013
Circadian rhythms, skeletal muscle molecular clocks, and exercise.
Exercise and sport sciences reviews.
41(4):224-9
[DOI] 10.1097/JES.0b013e3182a58a70.
[PMID] 23917214.
2013
Effect of gluteus medius muscle sample collection depth on postprandial mammalian target of rapamycin signaling in mature Thoroughbred mares.
American journal of veterinary research.
74(6):910-7
[DOI] 10.2460/ajvr.74.6.910.
[PMID] 23718660.
2013
Forum on bone and skeletal muscle interactions: summary of the proceedings of an ASBMR workshop.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
28(9):1857-65
[DOI] 10.1002/jbmr.1980.
[PMID] 23671010.
2013
Genome-wide expression analysis and EMX2 gene expression in embryonic myoblasts committed to diverse skeletal muscle fiber type fates.
Developmental dynamics : an official publication of the American Association of Anatomists.
242(8):1001-20
[DOI] 10.1002/dvdy.23988.
[PMID] 23703830.
2013
The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility.
American journal of physiology. Cell physiology.
304(10):C954-65
[DOI] 10.1152/ajpcell.00383.2012.
[PMID] 23364267.
2013
Time course of gene expression during mouse skeletal muscle hypertrophy.
Journal of applied physiology (Bethesda, Md. : 1985).
115(7):1065-74
[DOI] 10.1152/japplphysiol.00611.2013.
[PMID] 23869057.
2012
A non-canonical E-box within the MyoD core enhancer is necessary for circadian expression in skeletal muscle.
Nucleic acids research.
40(8):3419-30
[DOI] 10.1093/nar/gkr1297.
[PMID] 22210883.
2012
Correction: Inducible Cre transgenic mouse strain for skeletal muscle-specific gene targeting.
Skeletal muscle.
2(1)
[DOI] 10.1186/2044-5040-2-22.
[PMID] 23110921.
2012
Development of dilated cardiomyopathy in Bmal1-deficient mice.
American journal of physiology. Heart and circulatory physiology.
303(4):H475-85
[DOI] 10.1152/ajpheart.00238.2012.
[PMID] 22707558.
2012
Inducible Cre transgenic mouse strain for skeletal muscle-specific gene targeting.
Skeletal muscle.
2(1)
[DOI] 10.1186/2044-5040-2-8.
[PMID] 22564549.
2012
Perinatal exercise improves glucose homeostasis in adult offspring.
American journal of physiology. Endocrinology and metabolism.
303(8):E1061-8
[DOI] 10.1152/ajpendo.00213.2012.
[PMID] 22932781.
2012
Scheduled exercise phase shifts the circadian clock in skeletal muscle.
Medicine and science in sports and exercise.
44(9):1663-70
[DOI] 10.1249/MSS.0b013e318255cf4c.
[PMID] 22460470.
2012
VDR and CYP27B1 are expressed in C2C12 cells and regenerating skeletal muscle: potential role in suppression of myoblast proliferation.
American journal of physiology. Cell physiology.
303(4):C396-405
[DOI] 10.1152/ajpcell.00014.2012.
[PMID] 22648952.
2011
Age-associated disruption of molecular clock expression in skeletal muscle of the spontaneously hypertensive rat.
PloS one.
6(11)
[DOI] 10.1371/journal.pone.0027168.
[PMID] 22076133.
2011
Aging and microRNA expression in human skeletal muscle: a microarray and bioinformatics analysis.
Physiological genomics.
43(10):595-603
[DOI] 10.1152/physiolgenomics.00148.2010.
[PMID] 20876843.
2011
Circadian rhythms, the molecular clock, and skeletal muscle.
Current topics in developmental biology.
96:231-71
[DOI] 10.1016/B978-0-12-385940-2.00009-7.
[PMID] 21621073.
2011
Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling.
The Journal of physiology.
589(Pt 7):1831-46
[DOI] 10.1113/jphysiol.2011.205658.
[PMID] 21300751.
2011
Effective fiber hypertrophy in satellite cell-depleted skeletal muscle.
Development (Cambridge, England).
138(17):3657-66
[DOI] 10.1242/dev.068858.
[PMID] 21828094.
2011
Leukaemia inhibitory factor is expressed in rat gastrocnemius muscle after contusion and increases proliferation of rat L6 myoblasts via c-Myc signalling.
Clinical and experimental pharmacology & physiology.
38(8):501-9
[DOI] 10.1111/j.1440-1681.2011.05537.x.
[PMID] 21585421.
2010
Anabolic and catabolic pathways regulating skeletal muscle mass.
Current opinion in clinical nutrition and metabolic care.
13(3):230-5
[DOI] 10.1097/MCO.0b013e32833781b5.
[PMID] 20154608.
2010
CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function.
Proceedings of the National Academy of Sciences of the United States of America.
107(44):19090-5
[DOI] 10.1073/pnas.1014523107.
[PMID] 20956306.
2010
Comments on Point:Counterpoint: IGF is/is not the major physiological regulator of muscle mass. IGF-1 is not key for adult skeletal muscle hypertrophy.
Journal of applied physiology (Bethesda, Md. : 1985).
108(6)
[DOI] 10.1152/japplphysiol.00312.2010.
[PMID] 20527705.
2010
Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice.
The Journal of clinical investigation.
120(11):4007-20
[DOI] 10.1172/JCI42447.
[PMID] 20921627.
2010
Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes.
The FEBS journal.
277(9):2180-91
[DOI] 10.1111/j.1742-4658.2010.07635.x.
[PMID] 20412061.
2009
Cellular mechanisms regulating protein synthesis and skeletal muscle hypertrophy in animals.
Journal of applied physiology (Bethesda, Md. : 1985).
106(4):1367-73
[DOI] 10.1152/japplphysiol.91355.2008.
[PMID] 19036895.
2009
Evidence of MyomiR network regulation of beta-myosin heavy chain gene expression during skeletal muscle atrophy.
Physiological genomics.
39(3):219-26
[DOI] 10.1152/physiolgenomics.00042.2009.
[PMID] 19690046.
2009
Expression of growth-related genes in young and older human skeletal muscle following an acute stimulation of protein synthesis.
Journal of applied physiology (Bethesda, Md. : 1985).
106(4):1403-11
[DOI] 10.1152/japplphysiol.90842.2008.
[PMID] 18787087.
2009
FoxO1 induces apoptosis in skeletal myotubes in a DNA-binding-dependent manner.
American journal of physiology. Cell physiology.
297(3):C548-55
[DOI] 10.1152/ajpcell.00502.2008.
[PMID] 19553561.
2009
Physical activity reduces prostate carcinogenesis in a transgenic model.
The Prostate.
69(13):1372-7
[DOI] 10.1002/pros.20987.
[PMID] 19489028.
2009
REDD2 is enriched in skeletal muscle and inhibits mTOR signaling in response to leucine and stretch.
American journal of physiology. Cell physiology.
296(3):C583-92
[DOI] 10.1152/ajpcell.00464.2008.
[PMID] 19129461.
2009
The role of clock genes in cardiometabolic disease.
Journal of applied physiology (Bethesda, Md. : 1985).
107(4):1316-7
[DOI] 10.1152/japplphysiol.00939.2009.
[PMID] 19713427.
2009
Working around the clock: circadian rhythms and skeletal muscle.
Journal of applied physiology (Bethesda, Md. : 1985).
107(5):1647-54
[DOI] 10.1152/japplphysiol.00725.2009.
[PMID] 19696362.
2008
Aging differentially affects human skeletal muscle microRNA expression at rest and after an anabolic stimulus of resistance exercise and essential amino acids.
American journal of physiology. Endocrinology and metabolism.
295(6):E1333-40
[DOI] 10.1152/ajpendo.90562.2008.
[PMID] 18827171.
2008
Regulation of mTOR signaling in skeletal muscle hypertrophy.
Journal of musculoskeletal & neuronal interactions.
8(4):338-9
[PMID] 19147966.
2008
Regulation of skeletal muscle size, regeneration and repair.
Journal of musculoskeletal & neuronal interactions.
8(4):335-6
[PMID] 19147964.
2007
Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America.
104(9):3342-7
[PMID] 17360649.
2007
Counterpoint: Satellite cell addition is not obligatory for skeletal muscle hypertrophy.
Journal of applied physiology (Bethesda, Md. : 1985).
103(3):1100-2; discussion 1102
[PMID] 17724306.
2007
Gene expression responses over 24 h to lengthening and shortening contractions in human muscle: major changes in CSRP3, MUSTN1, SIX1, and FBXO32.
Physiological genomics.
31(1):42-52
[PMID] 17519359.
2007
Identification of the circadian transcriptome in adult mouse skeletal muscle.
Physiological genomics.
31(1):86-95
[PMID] 17550994.
2007
Last Word on Point:Counterpoint: Satellite cell addition is/is not obligatory for skeletal muscle hypertrophy.
Journal of applied physiology (Bethesda, Md. : 1985).
103(3)
[PMID] 17724310.
2007
MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy.
Journal of applied physiology (Bethesda, Md. : 1985).
102(1):306-13
[PMID] 17008435.
2007
MicroRNA-206 is overexpressed in the diaphragm but not the hindlimb muscle of mdx mouse.
American journal of physiology. Cell physiology.
293(1):C451-7
[PMID] 17459947.
2007
Voluntary wheel running ameliorates vascular smooth muscle hyper-contractility in type 2 diabetic db/db mice.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.
32(4):711-20
[PMID] 17622286.
2006
Anabolic signaling and protein synthesis in human skeletal muscle after dynamic shortening or lengthening exercise.
American journal of physiology. Endocrinology and metabolism.
290(4):E731-8
[PMID] 16263770.
2006
Expression of beta-catenin is necessary for physiological growth of adult skeletal muscle.
American journal of physiology. Cell physiology.
291(1):C185-8
[PMID] 16436469.
2005
Aging does not alter the mechanosensitivity of the p38, p70S6k, and JNK2 signaling pathways in skeletal muscle.
Journal of applied physiology (Bethesda, Md. : 1985).
98(4):1562-6
[PMID] 15361519.
2005
FoxO1 stimulates fatty acid uptake and oxidation in muscle cells through CD36-dependent and -independent mechanisms.
The Journal of biological chemistry.
280(14):14222-9
[PMID] 15691844.
2005
Intracellular signaling specificity in response to uniaxial vs. multiaxial stretch: implications for mechanotransduction.
American journal of physiology. Cell physiology.
288(1):C185-94
[PMID] 15371259.
2005
mTOR function in skeletal muscle hypertrophy: increased ribosomal RNA via cell cycle regulators.
American journal of physiology. Cell physiology.
289(6):C1457-65
[PMID] 16079186.
2005
Redox mechanisms of muscle dysfunction in inflammatory disease.
Physical medicine and rehabilitation clinics of North America.
16(4):925-49, ix
[PMID] 16214052.
2005
Wnt/beta-catenin signaling activates growth-control genes during overload-induced skeletal muscle hypertrophy.
American journal of physiology. Cell physiology.
289(4):C853-9
[PMID] 15888552.
2004
Altered activity of signaling pathways in diaphragm and tibialis anterior muscle of dystrophic mice.
Experimental biology and medicine (Maywood, N.J.).
229(6):503-11
[PMID] 15169969.
2004
GPx-1 modulates Akt and P70S6K phosphorylation and Gadd45 levels in MCF-7 cells.
Free radical biology & medicine.
37(2):187-95
[PMID] 15203190.
2004
Isoenergetic dietary protein restriction decreases myosin heavy chain IIx fraction and myosin heavy chain production in humans.
The Journal of nutrition.
134(2):328-34
[PMID] 14747668.
2004
Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism.
The Biochemical journal.
380(Pt 3):795-804
[PMID] 15030312.
2004
Mechanotransduction and the regulation of protein synthesis in skeletal muscle.
The Proceedings of the Nutrition Society.
63(2):331-5
[PMID] 15294051.
2003
Selenoprotein-deficient transgenic mice exhibit enhanced exercise-induced muscle growth.
The Journal of nutrition.
133(10):3091-7
[PMID] 14519790.
2003
The MEF2 site is necessary for induction of the myosin light chain 2 slow promoter in overloaded regenerating plantaris muscle.
Life sciences.
73(25):3265-76
[PMID] 14561531.
2002
Selenium influences the turnover of selenocysteine tRNA([Ser]Sec) in Chinese hamster ovary cells.
The Journal of nutrition.
132(7):1830-5
[PMID] 12097655.
2001
Intracellular signaling specificity in skeletal muscle in response to different modes of exercise.
Journal of applied physiology (Bethesda, Md. : 1985).
90(5):1936-42
[PMID] 11299288.
2000
Autocrine phosphorylation of p70(S6k) in response to acute stretch in myotubes.
Molecular cell biology research communications : MCBRC.
4(2):76-80
[PMID] 11170836.
2000
The calcineurin-NFAT pathway and muscle fiber-type gene expression.
American journal of physiology. Cell physiology.
279(4):C915-24
[PMID] 11003571.
1999
Extraction of nuclear proteins from striated muscle tissue.
BioTechniques.
26(2):202-4, 206
[PMID] 10023525.
1999
Phosphorylation of p70(S6k) correlates with increased skeletal muscle mass following resistance exercise.
The American journal of physiology.
276(1):C120-7
[DOI] 10.1152/ajpcell.1999.276.1.C120.
[PMID] 9886927.
1999
The CACC box and myocyte enhancer factor-2 sites within the myosin light chain 2 slow promoter cooperate in regulating nerve-specific transcription in skeletal muscle.
The Journal of biological chemistry.
274(17):12095-102
[PMID] 10207035.
1999
Transcriptional regulation in response to exercise.
Exercise and sport sciences reviews.
27:333-79
[PMID] 10791022.
1995
Mechanical load affects growth and maturation of skeletal muscle grafts.
Journal of applied physiology (Bethesda, Md. : 1985).
78(1):30-7
[PMID] 7713828.
1993
Adjuvant arthritic (AA) rats exhibit enhanced endotoxin-induced plasma TNF (EIPT) levels.
Agents and actions.
39 Spec No:C58-60
[PMID] 8273587.
1993
Identification of a program of contractile protein gene expression initiated upon skeletal muscle differentiation.
Developmental dynamics : an official publication of the American Association of Anatomists.
196(1):25-36
[PMID] 8334297.
1993
Nerve-dependent and -independent patterns of mRNA expression in regenerating skeletal muscle.
Developmental biology.
159(1):173-83
[PMID] 8365559.
1992
Age effects on myosin subunit and biochemical alterations with skeletal muscle hypertrophy.
Journal of applied physiology (Bethesda, Md. : 1985).
72(5):1934-9
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Disrupted circadian core-clock oscillations in Type 2 Diabetes are linked to altered rhythmic mitochondrial metabolism
.
[DOI] 10.1101/2021.02.24.432683.
Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and circadian rhythms
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Grants
Sep 2023
ACTIVE
Molecular Transducers of Physical Activity Consortium Coordinating Center
Role: Principal Investigator
Funding: WAKE FOREST UNIV
via NATL INST OF HLTH NIAMS
Jul 2023
ACTIVE
Renal Circadian Clock Protein Regulation of the Immune Response in Aging
Role: Other
Funding: AMER HEART ASSOCIATION
Jun 2023
ACTIVE
Longevity Consortium TOF: The role of molecular damage in muscle for muscle performance with aging
Role: Principal Investigator
Funding: CALIFORNIA PACIFIC MEDICAL CTR
via NATL INST OF HLTH NIA
Jun 2022
ACTIVE
University of Florida Claude D. Pepper Older Americans Independence Center
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Apr 2022
ACTIVE
Ciliary Hedgehog signaling during adult tissue repair and disease
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Jan 2022
ACTIVE
Molecular mechanisms linking contraction type to muscular adaptations and injury
Role: Principal Investigator
Funding: STANFORD UNIV
Mar 2021
ACTIVE
Circadian Clock and Muscle Health
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
Sep 2020
ACTIVE
Circadian clock regulation of myocardial ion channel expression and function
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Mar 2019
– Feb 2023
Transcriptional Regulation of KCNH2
Role: Principal Investigator
Funding: UNIV OF KENTUCKY
via NATL INST OF HLTH NHLBI
Jun 2018
ACTIVE
Study of muscle, mobility, and aging (SOMMA)
Role: Principal Investigator
Funding: CALIFORNIA PACIFIC MEDICAL CTR
via NATL INST OF HLTH NIA
Aug 2017
ACTIVE
Optimizing AAV Vectors for Central Nervous System transduction
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Jul 2017
– May 2022
The effect of intermittent hemidiaphragm stimulation during surgery on mitochondrial function, single fiber contractile force and catabolic pathways in humans
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Jul 2017
– Jun 2019
Hyperammonemia reduces skeletal muscle protein synthesis via a ?-catenin-cMyc mediated impaired ribosomal biogenesis
Role: Principal Investigator
Funding: CLEVELAND CLINIC FOU
via NATL INST OF HLTH NIAMS
May 2017
– Jun 2018
Gene therapy with intracranial delivery of capsid enhanced AAV NAGLU
Role: Co-Investigator
Funding: FUNDACJA SANFILIPPO
May 2017
– Aug 2019
The molecular clock and titin expression in skeletal muscle
Role: Other
Funding: NATL INST OF HLTH NIAMS
Feb 2017
– Jun 2018
A comprehensive atlas of transcriptome diversity in mouse skeletal muscle
Role: Principal Investigator
Funding: WASHINGTON UNIV SAINT LOUIS
via NATL INST OF HLTH NIAMS
Dec 2016
ACTIVE
UF PASS: Regulation of exercise transducers
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Dec 2016
– Sep 2023
MoTrPAC Consortium Coordinating Center
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
May 2016
– Jun 2019
Gene therapy with intracranial delivery of capsid enhanced AAV NAGLU
Role: Co-Investigator
Funding: SAN FILIPPO CHILDRENS FOU
May 2016
– Jun 2018
Gene therapy with intracranial delivery of capsid enhanced AAV NAGLU
Role: Co-Investigator
Funding: SANFILIPPO INITIATIVE E V
Apr 2016
– Mar 2017
Claude D Pepper Older Americans Independence Center
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Sep 2015
– Jun 2017
BETACATENIN REGULATION OF SKELETAL MUSCLE HYPERTROPHY
Role: Principal Investigator
Funding: UNIV OF KENTUCKY RESEARCH FOU
via NATL INST OF HLTH
Aug 2015
– Jul 2020
Molecular clock and skeletal muscle weakness
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
Education
PhD
1990
·
University of Michigan
Contact Details
Phones:
- Business:
- (352) 273-5728
Emails:
- Business:
- kaesser@ufl.edu
Addresses:
- Business Mailing:
-
M544
PO BOX 100274
DEPARTMENT OF PHYSIOLOGY AND AGING
GAINESVILLE FL 326100274 - Business Street:
-
PHYSIOLOGY AND AGING
M-544
GAINESVILLE FL 326100274