Charles E. Wood, Ph.D.

Professor and Chair

Wood Lab

Charles E. Wood, PhD

Phone: (352) 294-5064
Office: MSB M556
PubMed Listing


Education and Training/Previous Appointments


Research Interests

The research performed in the Wood laboratory is focused on the physiology of the late-gestation fetus and the mechanisms that ready the fetus for birth and transition to extrauterine life.  The Wood laboratory has contributed to our understanding of the responses to stress (hypoxia and hypotension) in the fetus in utero and on the mechanisms controlling the timing of birth.  This laboratory has published research results which have played a leading role in elucidating the function of the fetal arterial baroreceptors and chemoreceptors in the control of fetal cardiovascular and endocrine function.  Other research performed in this laboratory has identified the cardiovascular neural receptors which are involved in the integrated cardiovascular and endocrine response to alterations in blood gases and blood pressure in the fetus.  Complementary to this work has been discovery of the influence of the fetal endocrine systems, especially the hypothalamus-pituitary-adrenal axis and the adrenal-placental steroid axis, on the physiological mechanisms supporting survival and growth of the fetus.

Recent discoveries in this laboratory have focused on the intersection between stress, inflammation, and normal birth.  The laboratory has made seminal contributions to our understanding of the role that prostaglandins play in fetal development.  Recently, collaborative work between the Wood laboratory and the Triplett laboratory in the College of Agriculture and Life Sciences has discovered that fetal brain inflammation after fetal and maternal stress is caused by movement of live bacteria from the mother to the fetus.  This new discovery has the potential to change treatment to prevent hypoxic-ischemic encephalopathy in the newborn infant.

Together, the studies performed in the Wood laboratory interrelate to advance our knowledge of normal and abnormal fetal development, with the ultimate goal of improving outcomes for babies.

Teaching (Including Courses)

  • Physiology Grant Writing (GMS5905)
  • Medical Endocrine and Reproductive Physiology (GMS 6419)
  • Fundamentals of Physiology and Functional Genomics 2 (GMS 6472)

Awards and Honors


PubMed Listing

  • Rabaglino, M. B., Keller-Wood, M., & Wood, C. E. (2018). A transcriptomics model of estrogen action in the ovine fetal hypothalamus: evidence for estrogenic effects of ICI 182,780. Physiological reports, 6(18), e13871. (PMID: 30221477; PMCID: PMC6139289)
  • Zarate, M. A., Chang, E. I., & Wood, C. E. (2018). Effects of ketamine on the fetal transcriptomic response to umbilical cord occlusion: comparison with hypoxic hypoxia in the cerebral cortex. Journal of physiology, Jun 8. doi: 10.1113/JP275661. (PMID: 29882596)
  • Jackson, E. N., Rowland-Faux, L., James, M. O., & Wood, C. E. (2018). Administration of low dose triclosan to pregnant ewes results in placental uptake and reduced estradiol sulfotransferase activity in fetal liver and placenta. Toxicology letters, 294, 116-121. doi: 10.1016/j.toxlet.2018.05.014. (PMID: 29772265; PMCID: PMC6026481)
  • Wood, C. E. (2018). Fetal growth: too little or just right? The Journal of Physiology, Jan 15. doi: 10.1113/JP275612. (PMID: 29336048)
  • Rodriguez, M. D., Paul, Z., Wood, C. E., Rice, K. C., & Triplett, E. W. (2017). Construction of Stable Fluorescent Reporter Plasmids for Use in Staphylococcus aureusFrontiers in microbiology, 8, 2491. doi:10.3389/fmicb.2017.02491. (PMID: 29312199; PMCID: PMC5735104)
  • Antolic, A., Wood, C. E., & Keller-Wood, M. (2018). Chronic maternal hypercortisolemia in late gestation alters fetal cardiac function at birth. American journal of physiology. Regulatory, integrative, and comparative physiology, 314(3), R342-R352. doi: 10.1152/ajpregu.00296.2017. (PMID: 29092858; PMCID: PMC5899252)
  • Antolic, A., Wood, C. E., & Keller-Wood, M. (2018). Use of radiotelemetry to assess perinatal cardiac function in the ovine fetus and newborn. American journal of physiology. Regulatory, integrative, and comparative physiology, 313(6), R660-R668. doi: 10.1152/ajpregu.00078.2017. (PMID: 28855176; PMCID: PMC5814690)
  • Zarate, M. A., Rodriguez, M. D., Chang, E. I., Russell, J. T., Arndt, T. J., Richards, E. M., Ocasio, B. A., Aranda, E., Gordon, E. M., Yu, K., Neu, J., Keller-Wood, M., Triplett, E. W., … Wood, C. E. (2017). Post-hypoxia Invasion of the fetal brain by multidrug resistant Staphylococcus. Scientific reports, 7(1), 6458. doi:10.1038/s41598-017-06789-6. PMID: 28743956; PMCID: PMC5527097)
  • Zarate, M. A., Chang, E. I., Antolic, A., & Wood, C. E. (2016). Ketamine modulates fetal hemodynamic and endocrine responses to umbilical cord occlusion. Physiological reports, 4(17), e12962. (PMID: 27597770; PMCID: PMC5027363)
  • Rabaglino, M. B., Chang, E. I., Richards, E. M., James, M. O., Keller-Wood, M., & Wood, C. E. (2016). Genomic Effect of Triclosan on the Fetal Hypothalamus: Evidence for Altered Neuropeptide Regulation. Endocrinology, 157(7), 2686-97. (PMID: 27145008; PMCID: PMC4929550)