Helen N Jones, PhD
Associate Professor
Department:
Department of Physiology and Aging
Business Phone:
(352) 846-1503
Business Email:
jonesh@ufl.edu
About Helen N Jones
Additional Positions:
Associate Professor
2020 – Current
·
Physiology and Aging
Teaching Profile
Courses Taught
2021-2024
GMS6495 Seminar in Physiology
2021-2024
PAS5025 Human Physiology
2022-2025
DEN5120C Physiology
2023
ANS6751 Physiology of Reproduction
2023-2025
GMS6491 Journal Club in Physiology
2023-2024
BMS6632 Endo and Reproduction
2023-2025
ANS5935 Reproductive Biology Seminar and Research Studies
2024-2025
BMS3521 Human Physiology in Translation
Publications
Academic Articles
2025
Late gestation heat stress alters O2 regulation in placenta and neonatal heifers.
Placenta.
159:126-130
[DOI] 10.1016/j.placenta.2024.12.009.
[PMID] 39708414.
2025
Maternal-fetal interfaces transcriptome changes associated with placental insufficiency and a novel gene therapy intervention
Physiological Genomics.
57(1):8-15
[DOI] 10.1152/physiolgenomics.00131.2024.
[PMID] 39374081.
2025
Mid-Pregnancy Placental Transcriptome in a Model of Placental Insufficiency with and without Novel Intervention.
Reproductive sciences (Thousand Oaks, Calif.).
32(2):435-443
[DOI] 10.1007/s43032-024-01769-4.
[PMID] 39707140.
2025
Placenta hIGF1 nanoparticle treatment in guinea pigs mitigates FGR-associated fetal sex-dependent effects on liver metabolism-related signaling pathways
American Journal of Physiology-Endocrinology and Metabolism.
328(3):E395-E409
[DOI] 10.1152/ajpendo.00440.2024.
2024
A genome scale transcriptional regulatory model of the human placenta
Science Advances.
10(26)
[DOI] 10.1126/sciadv.adf3411.
[PMID] 38941464.
2024
Nanoparticle-mediated delivery of placental gene therapy via uterine artery catheterization in a pregnant rhesus macaque
Placenta.
[DOI] 10.1016/j.placenta.2024.09.013.
[PMID] 39362807.
2024
Placental gene therapy in nonhuman primates: a pilot study of maternal, placental, and fetal response to non-viral, polymeric nanoparticle delivery of IGF1
Molecular Human Reproduction.
30(11)
[DOI] 10.1093/molehr/gaae038.
[PMID] 39499161.
2024
Placental nanoparticle-mediated IGF1 gene therapy corrects fetal growth restriction in a guinea pig model.
Gene therapy.
[DOI] 10.1038/s41434-024-00508-3.
[PMID] 39627510.
2023
Characterization of methylation profiles in spontaneous preterm birth placental villous tissue.
PloS one.
18(3)
[DOI] 10.1371/journal.pone.0279991.
[PMID] 36952446.
2023
HAND1 knockdown disrupts trophoblast global gene expression
Physiological Reports.
11(2)
[DOI] 10.14814/phy2.15553.
[PMID] 36695714.
2023
Neonatal Depression Is Associated With 1‐Year Mortality in Critical Congenital Heart Disease
Journal of the American Heart Association.
12(11)
[DOI] 10.1161/jaha.122.028774.
2023
Placental nanoparticle gene therapy normalizes gene expression changes in the fetal liver associated with fetal growth restriction in a fetal sex-specific manner.
Journal of developmental origins of health and disease.
14(3):325-332
[DOI] 10.1017/S2040174423000016.
[PMID] 36794386.
2022
Analysis of commonly expressed genes between first trimester fetal heart and placenta cell types in the context of congenital heart disease.
Scientific reports.
12(1)
[DOI] 10.1038/s41598-022-14955-8.
[PMID] 35750800.
2022
Assessment of human milk in the era of precision health.
Current opinion in clinical nutrition and metabolic care.
25(5):292-297
[DOI] 10.1097/MCO.0000000000000860.
[PMID] 35838294.
2022
Interventions for placental insufficiency and fetal growth restriction.
Placenta.
125:4-9
[DOI] 10.1016/j.placenta.2022.03.127.
[PMID] 35414477.
2022
Nanoparticle-mediated transgene expression of insulin-like growth factor 1 in the growth restricted guinea pig placenta increases placenta nutrient transporter expression and fetal glucose concentrations.
Molecular reproduction and development.
89(11):540-553
[DOI] 10.1002/mrd.23644.
[PMID] 36094907.
2022
Placental and fetal characteristics of the Ohia mouse line recapitulate outcomes in human hypoplastic left heart syndrome.
Placenta.
117:131-138
[DOI] 10.1016/j.placenta.2021.12.001.
[PMID] 34890862.
2022
Placental treatment with insulin-like growth factor 1 via nanoparticle differentially impacts vascular remodeling factors in guinea pig sub-placenta/decidua.
Frontiers in physiology.
13
[DOI] 10.3389/fphys.2022.1055234.
[PMID] 36685211.
2022
Roles of maternal HDL during pregnancy.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
1867(3)
[DOI] 10.1016/j.bbalip.2021.159106.
[PMID] 34995789.
2021
Conditional Mutation of Hand1 in the Mouse Placenta Disrupts Placental Vascular Development Resulting in Fetal Loss in Both Early and Late Pregnancy.
International journal of molecular sciences.
22(17)
[DOI] 10.3390/ijms22179532.
[PMID] 34502440.
2021
Insulin-like growth factor 1 signaling in the placenta requires endothelial nitric oxide synthase to support trophoblast function and normal fetal growth.
American journal of physiology. Regulatory, integrative and comparative physiology.
320(5):R653-R662
[DOI] 10.1152/ajpregu.00250.2020.
[PMID] 33621475.
2021
Sexual dimorphisms in brain gene expression in the growth-restricted guinea pig can be modulated with intra-placental therapy.
Pediatric research.
89(7):1673-1680
[DOI] 10.1038/s41390-021-01362-4.
[PMID] 33531677.
2021
Targeting the Dysfunctional Placenta to Improve Pregnancy Outcomes Based on Lessons Learned in Cancer
Clinical Therapeutics.
43(2):246-264
[DOI] 10.1016/j.clinthera.2020.12.007.
[PMID] 33446335.
2021
Time Mating Guinea Pigs by Monitoring Changes to the Vaginal Membrane throughout the Estrus Cycle and with Ultrasound Confirmation.
Methods and protocols.
4(3)
[DOI] 10.3390/mps4030058.
[PMID] 34564304.
2021
‘Fetal side’ of the placenta: anatomical mis-annotation of carbon particle ‘transfer’ across the human placenta
Nature Communications.
12(1)
[DOI] 10.1038/s41467-021-26437-y.
[PMID] 34862366.
2020
Abnormalities of placental development and function are associated with the different fetal growth patterns of hypoplastic left heart syndrome and transposition of the great arteries.
Placenta.
101:57-65
[DOI] 10.1016/j.placenta.2020.09.007.
[PMID] 32927345.
2019
Gab3 is required for IL-2– and IL-15–induced NK cell expansion and limits trophoblast invasion during pregnancy
Science Immunology.
4(38)
[DOI] 10.1126/sciimmunol.aav3866.
[PMID] 31375526.
Abnormalities of placental development and function are associated with the different fetal growth patterns of hypoplastic left heart syndrome and transposition of the great arteries
.
[DOI] 10.1101/388074.
Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births
.
[DOI] 10.1101/386185.
Grants
Sep 2024
ACTIVE
Tipler- APS-Porter Physiology Development Fellowship
Role: Other
Funding: AMER PHYSIOLOGICAL SOC
Aug 2024
ACTIVE
Clinical, Histological, and Transcriptional Associations Between the Diabetic Placenta and Fetal Congenital Heart Defects
Role: Other
Funding: NATL INST OF HLTH NHLBI
Aug 2024
ACTIVE
Placental-specific therapy for fetal growth restriction
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD
Dec 2023
ACTIVE
Tolerance signals from human pregnancy for beta cell replacement therapy
Role: Co-Investigator
Funding: BREAKTHROUGH T1D – formerly JDRF Intl
Aug 2023
ACTIVE
Efficacy and safety of nanoparticle mediated placental gene therapy in nonhuman primates
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD
Jul 2023
ACTIVE
Developmental Programming of the Liver and Kidney in Fetal Growth with or without Gene Therapy
Role: Other
Funding: NATL INST OF HLTH NICHD
Aug 2020
– Jun 2022
Harnessing "omics": A Systems Biology approach to discovery of biologicalpathways in placental development and parturition
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD
Aug 2020
– Jun 2023
Placental-specific therapy for fetal growth restriction
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD
Jul 2020
ACTIVE
International Federation of Placenta Associations
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD
Contact Details
Phones:
- Business:
- (352) 846-1503
Emails:
- Business:
- jonesh@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100274
Department of Physiology and Aging
GAINESVILLE FL 32610