Helen N Jones

Helen N Jones, Ph.D.

Co-Director, Center for Research in Perinatal Outcomes

Department: Department of Physiology and Aging
Business Phone: (352) 846-1503
Business Email: jonesh@ufl.edu

About Helen N Jones

Additional Positions:
Co-Director
2020 – Current · Center for Research in Perinatal Outcomes

Teaching Profile

Courses Taught
2021-2025
GMS6495 Seminar in Physiology
2021-2023
PAS5025 Human Physiology
2022-2025
DEN5120C Physiology
2023
ANS6751 Physiology of Reproduction
2023-2025
GMS6491 Journal Club in Physiology
2023-2025
BMS6632 Endo and Reproduction
2023-2025
ANS5935 Reproductive Biology Seminar and Research Studies
2024-2025
BMS3521 Human Physiology in Translation

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0001-7356-8420

Publications

2023
HAND1 knockdown disrupts trophoblast global gene expression
Physiological Reports. 11(2) [DOI] 10.14814/phy2.15553. [PMID] 36695714.
2023
Characterization of methylation profiles in spontaneous preterm birth placental villous tissue.
PloS one. 18(3) [DOI] 10.1371/journal.pone.0279991. [PMID] 36952446.
2023
Neonatal Depression Is Associated With 1‐Year Mortality in Critical Congenital Heart Disease
Journal of the American Heart Association. 12(11) [DOI] 10.1161/jaha.122.028774.
2023
Placental nanoparticle gene therapy normalizes gene expression changes in the fetal liver associated with fetal growth restriction in a fetal sex-specific manner.
Journal of developmental origins of health and disease. 14(3):325-332 [DOI] 10.1017/S2040174423000016. [PMID] 36794386.
2022
Analysis of commonly expressed genes between first trimester fetal heart and placenta cell types in the context of congenital heart disease.
Scientific reports. 12(1) [DOI] 10.1038/s41598-022-14955-8. [PMID] 35750800.
2022
Assessment of human milk in the era of precision health.
Current opinion in clinical nutrition and metabolic care. 25(5):292-297 [DOI] 10.1097/MCO.0000000000000860. [PMID] 35838294.
2022
Interventions for placental insufficiency and fetal growth restriction.
Placenta. 125:4-9 [DOI] 10.1016/j.placenta.2022.03.127. [PMID] 35414477.
2022
Nanoparticle-mediated transgene expression of insulin-like growth factor 1 in the growth restricted guinea pig placenta increases placenta nutrient transporter expression and fetal glucose concentrations.
Molecular reproduction and development. 89(11):540-553 [DOI] 10.1002/mrd.23644. [PMID] 36094907.
2022
Placental and fetal characteristics of the Ohia mouse line recapitulate outcomes in human hypoplastic left heart syndrome.
Placenta. 117:131-138 [DOI] 10.1016/j.placenta.2021.12.001. [PMID] 34890862.
2022
Placental treatment with insulin-like growth factor 1 via nanoparticle differentially impacts vascular remodeling factors in guinea pig sub-placenta/decidua.
Frontiers in physiology. 13 [DOI] 10.3389/fphys.2022.1055234. [PMID] 36685211.
2022
Roles of maternal HDL during pregnancy.
Biochimica et biophysica acta. Molecular and cell biology of lipids. 1867(3) [DOI] 10.1016/j.bbalip.2021.159106. [PMID] 34995789.
2021
Conditional Mutation of Hand1 in the Mouse Placenta Disrupts Placental Vascular Development Resulting in Fetal Loss in Both Early and Late Pregnancy.
International journal of molecular sciences. 22(17) [DOI] 10.3390/ijms22179532. [PMID] 34502440.
2021
Insulin-like growth factor 1 signaling in the placenta requires endothelial nitric oxide synthase to support trophoblast function and normal fetal growth.
American journal of physiology. Regulatory, integrative and comparative physiology. 320(5):R653-R662 [DOI] 10.1152/ajpregu.00250.2020. [PMID] 33621475.
2021
Sexual dimorphisms in brain gene expression in the growth-restricted guinea pig can be modulated with intra-placental therapy.
Pediatric research. 89(7):1673-1680 [DOI] 10.1038/s41390-021-01362-4. [PMID] 33531677.
2021
Targeting the Dysfunctional Placenta to Improve Pregnancy Outcomes Based on Lessons Learned in Cancer
Clinical Therapeutics. 43(2):246-264 [DOI] 10.1016/j.clinthera.2020.12.007.
2021
Time Mating Guinea Pigs by Monitoring Changes to the Vaginal Membrane throughout the Estrus Cycle and with Ultrasound Confirmation.
Methods and protocols. 4(3) [DOI] 10.3390/mps4030058. [PMID] 34564304.
2021
‘Fetal side’ of the placenta: anatomical mis-annotation of carbon particle ‘transfer’ across the human placenta
Nature Communications. 12(1) [DOI] 10.1038/s41467-021-26437-y. [PMID] 34862366.
2020
Abnormalities of placental development and function are associated with the different fetal growth patterns of hypoplastic left heart syndrome and transposition of the great arteries.
Placenta. 101:57-65 [DOI] 10.1016/j.placenta.2020.09.007. [PMID] 32927345.
2019
Gab3 is required for IL-2– and IL-15–induced NK cell expansion and limits trophoblast invasion during pregnancy
Science Immunology. 4(38) [DOI] 10.1126/sciimmunol.aav3866. [PMID] 31375526.
Abnormalities of placental development and function are associated with the different fetal growth patterns of hypoplastic left heart syndrome and transposition of the great arteries
. [DOI] 10.1101/388074.
Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births
. [DOI] 10.1101/386185.

Grants

Dec 2023 ACTIVE
Tolerance signals from human pregnancy for beta cell replacement therapy
Role: Co-Investigator
Funding: BREAKTHROUGH T1D – formerly JDRF Intl
Aug 2023 ACTIVE
Efficacy and safety of nanoparticle mediated placental gene therapy in nonhuman primates
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD
Jul 2023 ACTIVE
Developmental Programming of the Liver and Kidney in Fetal Growth with or without Gene Therapy
Role: Other
Funding: NATL INST OF HLTH NICHD
Aug 2020 – Jun 2022
Harnessing "omics": A Systems Biology approach to discovery of biologicalpathways in placental development and parturition
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD
Aug 2020 – Jun 2023
Placental-specific therapy for fetal growth restriction
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD
Jul 2020 ACTIVE
International Federation of Placenta Associations
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD

Contact Details

Phones:
Business:
(352) 846-1503
Emails:
Business:
jonesh@ufl.edu
Addresses:
Business Mailing:
PO Box 100274
Department of Physiology and Functional Genomics
GAINESVILLE FL 32610