Rebecca L Wilson,
RES AST PROF
Department:
Department of Physiology and Aging
Business Phone:
(352) 846-0586
Business Email:
rebecca.wilson@ufl.edu
Teaching Profile
Courses Taught
2023-2024
GMS6491 Journal Club in Physiology
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-3867-7784
Areas of Interest
- Developmental Origins of Health and Disease
- Fetal Development
- Maternal and Child Health
- Medical complications of pregnancy
- Placenta
- Pregnancy Therapies
Publications
2024
Maternal-fetal interfaces transcriptome changes associated with placental insufficiency and a novel gene therapy intervention.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.06.05.597595.
[PMID] 38895421.
2024
Mid-pregnancy placental transcriptome in a model of placental insufficiency with and without novel intervention.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.06.05.597621.
[PMID] 38895312.
2024
Nanoparticle-mediated delivery of placental gene therapy via uterine artery catheterization in a pregnant rhesus macaque.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.04.10.588902.
[PMID] 38645086.
2024
Placental Nanoparticle-mediated IGF1 Gene Therapy Corrects Fetal Growth Restriction in a Guinea Pig Model.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.04.05.587765.
[PMID] 38645174.
2023
HAND1 knockdown disrupts trophoblast global gene expression
Physiological Reports.
11(2)
[DOI] 10.14814/phy2.15553.
[PMID] 36695714.
2023
Maternal, placental and fetal response to a non-viral, polymeric nanoparticle gene therapy in nonhuman primates.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.06.16.545278.
[PMID] 38168281.
2023
Placental nanoparticle gene therapy normalizes gene expression changes in the fetal liver associated with fetal growth restriction in a fetal sex-specific manner
Developmental Origins of Health and Disease.
[DOI] Forthcoming.
2023
Placental nanoparticle gene therapy normalizes gene expression changes in the fetal liver associated with fetal growth restriction in a fetal sex-specific manner
Journal of Developmental Origins of Health and Disease.
14(3):325-332
[DOI] 10.1017/s2040174423000016.
2022
Analysis of commonly expressed genes between first trimester fetal heart and placenta cell types in the context of congenital heart disease.
Scientific reports.
12(1)
[DOI] 10.1038/s41598-022-14955-8.
[PMID] 35750800.
2022
Interventions for placental insufficiency and fetal growth restriction.
Placenta.
125:4-9
[DOI] 10.1016/j.placenta.2022.03.127.
[PMID] 35414477.
2022
Nanoparticle‐mediated transgene expression of
insulin‐like growth factor 1
in the growth restricted guinea pig placenta increases placenta nutrient transporter expression and fetal glucose concentrations
Molecular Reproduction and Development.
89(11):540-553
[DOI] 10.1002/mrd.23644.
[PMID] 36094907.
2022
Placental and fetal characteristics of the Ohia mouse line recapitulate outcomes in human hypoplastic left heart syndrome
Placenta.
117:131-138
[DOI] 10.1016/j.placenta.2021.12.001.
2022
Placental treatment with insulin-like growth factor 1 via nanoparticle differentially impacts vascular remodeling factors in guinea pig sub-placenta/decidua.
Frontiers in physiology.
13
[DOI] 10.3389/fphys.2022.1055234.
[PMID] 36685211.
2021
A sexually dimorphic murine model of IUGR induced by embryo transfer.
Reproduction (Cambridge, England).
161(2):135-144
[DOI] 10.1530/REP-20-0209.
[PMID] 33434162.
2021
Conditional Mutation of Hand1 in the Mouse Placenta Disrupts Placental Vascular Development Resulting in Fetal Loss in Both Early and Late Pregnancy.
International journal of molecular sciences.
22(17)
[DOI] 10.3390/ijms22179532.
[PMID] 34502440.
2021
Insulin-like growth factor 1 signaling in the placenta requires endothelial nitric oxide synthase to support trophoblast function and normal fetal growth
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.
320(5):R653-R662
[DOI] 10.1152/ajpregu.00250.2020.
[PMID] 33621475.
2021
Sexual dimorphisms in brain gene expression in the growth-restricted guinea pig can be modulated with intra-placental therapy
Pediatric Research.
89(7):1673-1680
[DOI] 10.1038/s41390-021-01362-4.
[PMID] 33531677.
2021
Targeting the Dysfunctional Placenta to Improve Pregnancy Outcomes Based on Lessons Learned in Cancer
Clinical Therapeutics.
43(2):246-264
[DOI] 10.1016/j.clinthera.2020.12.007.
2021
Time Mating Guinea Pigs by Monitoring Changes to the Vaginal Membrane throughout the Estrus Cycle and with Ultrasound Confirmation.
Methods and protocols.
4(3)
[DOI] 10.3390/mps4030058.
[PMID] 34564304.
2020
Nanoparticle mediated increased insulin-like growth factor 1 expression enhances human placenta syncytium function.
Placenta.
93:1-7
[DOI] 10.1016/j.placenta.2020.02.006.
[PMID] 32090963.
2020
Pregnancy, but not dietary octanoic acid supplementation, stimulates the ghrelin-pituitary growth hormone axis in mice.
The Journal of endocrinology.
245(2):327-342
[DOI] 10.1530/JOE-20-0072.
[PMID] 32176867.
2020
Reduced Dietary Calcium and Vitamin D Results in Preterm Birth and Altered Placental Morphogenesis in Mice During Pregnancy.
Reproductive sciences (Thousand Oaks, Calif.).
27(6):1330-1339
[DOI] 10.1007/s43032-019-00116-2.
[PMID] 32046423.
2019
Characterization of 5-methylcytosine and 5-hydroxymethylcytosine in human placenta cell types across gestation
Epigenetics.
14(7):660-671
[DOI] 10.1080/15592294.2019.1609866.
[PMID] 31038385.
2019
Maternal Selenium, Copper and Zinc Concentrations in Early Pregnancy, and the Association with Fertility
Nutrients.
11(7)
[DOI] 10.3390/nu11071609.
[PMID] 31315178.
2019
Validation studies of a fluorescent method to measure placental glucose transport in mice.
Placenta.
76:23-29
[DOI] 10.1016/j.placenta.2019.01.014.
[PMID] 30803711.
2018
Early pregnancy maternal trace mineral status and the association with adverse pregnancy outcome in a cohort of Australian women.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
46:103-109
[DOI] 10.1016/j.jtemb.2017.11.016.
[PMID] 29413099.
2018
Isolation of villous cytotrophoblasts from second trimester human placentas.
Placenta.
74:55-58
[DOI] 10.1016/j.placenta.2018.11.007.
[PMID] 30541665.
2018
Pre-pregnancy fast food and fruit intake is associated with time to pregnancy.
Human reproduction (Oxford, England).
33(6):1063-1070
[DOI] 10.1093/humrep/dey079.
[PMID] 29733398.
2018
Vitamin D levels in an Australian and New Zealand cohort and the association with pregnancy outcome.
BMC pregnancy and childbirth.
18(1)
[DOI] 10.1186/s12884-018-1887-x.
[PMID] 29925344.
2017
Zinc is a critical regulator of placental morphogenesis and maternal hemodynamics during pregnancy in mice.
Scientific reports.
7(1)
[DOI] 10.1038/s41598-017-15085-2.
[PMID] 29123159.
2016
Association between Maternal Zinc Status, Dietary Zinc Intake and Pregnancy Complications: A Systematic Review.
Nutrients.
8(10)
[PMID] 27754451.
2015
The effect of Vdr gene ablation on global gene expression in the mouse placenta.
Genomics data.
6:72-3
[DOI] 10.1016/j.gdata.2015.08.022.
[PMID] 26697339.
2015
Vitamin D Receptor Gene Ablation in the Conceptus Has Limited Effects on Placental Morphology, Function and Pregnancy Outcome.
PloS one.
10(6)
[DOI] 10.1371/journal.pone.0131287.
[PMID] 26121239.
Grants
Aug 2024
ACTIVE
Placental-specific therapy for fetal growth restriction
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
Aug 2023
ACTIVE
Efficacy and safety of nanoparticle mediated placental gene therapy in nonhuman primates
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
Jul 2023
ACTIVE
Developmental Programming of the Liver and Kidney in Fetal Growth with or without Gene Therapy
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD
Contact Details
Phones:
- Business:
- (352) 846-0586
Emails:
- Business:
- rebecca.wilson@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100274
Physiology and Aging
GAINESVILLE FL 32611