Tanja Taivassalo

Tanja Taivassalo,

RES ASO PROF

Department: Department of Physiology and Aging
Business Phone: (352) 339-6666
Business Email: ttaivassalo@ufl.edu

Teaching Profile

Courses Taught
2020-2023
PAS5025 Human Physiology
2020-2024
GMS6440 Fundamentals of Medical Physiology
2020-2021
GMS5905 Special Topics in Biomedical Sciences
2017-2019
APK4120 Clinical Exercise Physiology
2017
PET5936 Special Topics/Seminars
2020-2022,2024
BMS3521 Human Physiology in Translation
2022-2024
GMS6740 Neuromuscular Diseases

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0001-8923-2921

Publications

2023
OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases.
Communications biology. 6(1) [DOI] 10.1038/s42003-022-04303-x. [PMID] 36635485.
2022
Chronic aryl hydrocarbon receptor activity phenocopies smoking-induced skeletal muscle impairment.
Journal of cachexia, sarcopenia and muscle. 13(1):589-604 [DOI] 10.1002/jcsm.12826. [PMID] 34725955.
2022
Commentaries on Viewpoint: Hoping for the best, prepared for the worst: can we perform remote data collection in sport sciences?
Journal of applied physiology (Bethesda, Md. : 1985). 133(6):1433-1440 [DOI] 10.1152/japplphysiol.00613.2022. [PMID] 36509417.
2022
Integrating Mechanisms of Exacerbated Atrophy and Other Adverse Skeletal Muscle Impact in COPD.
Frontiers in physiology. 13 [DOI] 10.3389/fphys.2022.861617. [PMID] 35721564.
2022
Unbiased proteomics, histochemistry, and mitochondrial DNA copy number reveal better mitochondrial health in muscle of high-functioning octogenarians.
eLife. 11 [DOI] 10.7554/eLife.74335. [PMID] 35404238.
2021
Postcontractile blood oxygenation level-dependent (BOLD) response in Duchenne muscular dystrophy.
Journal of applied physiology (Bethesda, Md. : 1985). 131(1):83-94 [DOI] 10.1152/japplphysiol.00634.2020. [PMID] 34013753.
2021
Safety, feasibility, and efficacy of strengthening exercise in Duchenne muscular dystrophy.
Muscle & nerve. 63(3):320-326 [DOI] 10.1002/mus.27137. [PMID] 33295018.
2021
Walking activity in a large cohort of boys with Duchenne muscular dystrophy.
Muscle & nerve. 63(2):192-198 [DOI] 10.1002/mus.27119. [PMID] 33188573.
2019
Fidelity of muscle fibre reinnervation modulates ageing muscle impact in elderly women.
The Journal of physiology. 597(19):5009-5023 [DOI] 10.1113/JP278261. [PMID] 31368533.
2017
Common data elements for clinical research in mitochondrial disease: a National Institute for Neurological Disorders and Stroke project.
Journal of inherited metabolic disease. 40(3):403-414 [DOI] 10.1007/s10545-017-0035-5. [PMID] 28303425.
2017
Eccentric Ergometer Training Promotes Locomotor Muscle Strength but Not Mitochondrial Adaptation in Patients with Severe Chronic Obstructive Pulmonary Disease.
Frontiers in physiology. 8 [DOI] 10.3389/fphys.2017.00114. [PMID] 28316572.
2017
Eccentric Exercise and the Critically Ill Patient.
Frontiers in physiology. 8 [DOI] 10.3389/fphys.2017.00120. [PMID] 28293200.
2016
Addressing Assumptions for the Use of Non-invasive Cardiac Output Measurement Techniques During Exercise in COPD.
COPD. 13(1):75-81 [DOI] 10.3109/15412555.2015.1043985. [PMID] 26408087.
2016
Contribution of the Mitochondria to Locomotor Muscle Dysfunction in Patients With COPD.
Chest. 149(5):1302-12 [DOI] 10.1016/j.chest.2015.11.021. [PMID] 26836890.
2016
Denervation drives mitochondrial dysfunction in skeletal muscle of octogenarians.
The Journal of physiology. 594(24):7361-7379 [DOI] 10.1113/JP272487. [PMID] 27619626.
2016
Failed upregulation of TFAM protein and mitochondrial DNA in oxidatively deficient fibers of chronic obstructive pulmonary disease locomotor muscle.
Skeletal muscle. 6 [DOI] 10.1186/s13395-016-0083-9. [PMID] 26893822.
2016
Lung Function and Bronchial Hyperresponsiveness in Adults Born Prematurely. A Cohort Study.
Annals of the American Thoracic Society. 13(1):17-24 [DOI] 10.1513/AnnalsATS.201508-553OC. [PMID] 26523350.
2016
Motor unit number and transmission stability in octogenarian world class athletes: Can age-related deficits be outrun?
Journal of applied physiology (Bethesda, Md. : 1985). 121(4):1013-1020 [DOI] 10.1152/japplphysiol.00149.2016. [PMID] 27013605.
2016
Reduction in single muscle fiber rate of force development with aging is not attenuated in world class older masters athletes.
American journal of physiology. Cell physiology. 310(4):C318-27 [DOI] 10.1152/ajpcell.00289.2015. [PMID] 26632598.
2015
Anthracycline-containing chemotherapy causes long-term impairment of mitochondrial respiration and increased reactive oxygen species release in skeletal muscle.
Scientific reports. 5 [DOI] 10.1038/srep08717. [PMID] 25732599.
2015
Lactate and Energy Metabolism During Exercise in Patients With Blocked Glycogenolysis (McArdle Disease).
The Journal of clinical endocrinology and metabolism. 100(8):E1096-104 [DOI] 10.1210/jc.2015-1339. [PMID] 26030324.
2014
An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine. 189(9):e15-62 [DOI] 10.1164/rccm.201402-0373ST. [PMID] 24787074.
2014
Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 28(4):1621-33 [DOI] 10.1096/fj.13-242750. [PMID] 24371120.
2014
Physiological mechanisms of sex differences in exertional dyspnoea: role of neural respiratory motor drive.
Experimental physiology. 99(2):427-41 [DOI] 10.1113/expphysiol.2013.074880. [PMID] 24213856.
2014
The relationship between muscle fiber type-specific PGC-1α content and mitochondrial content varies between rodent models and humans.
PloS one. 9(8) [DOI] 10.1371/journal.pone.0103044. [PMID] 25121500.
2013
Autophagy in locomotor muscles of patients with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine. 188(11):1313-20 [DOI] 10.1164/rccm.201304-0732OC. [PMID] 24228729.
2012
Cytochrome c oxidase-intermediate fibres: importance in understanding the pathogenesis and treatment of mitochondrial myopathy.
Neuromuscular disorders : NMD. 22(8):690-8 [DOI] 10.1016/j.nmd.2012.04.003. [PMID] 22647770.
2012
Increased capillaries in mitochondrial myopathy: implications for the regulation of oxygen delivery.
Brain : a journal of neurology. 135(Pt 1):53-61 [DOI] 10.1093/brain/awr293. [PMID] 22232594.
2012
Mitochondrial dysfunction and lipid accumulation in the human diaphragm during mechanical ventilation.
American journal of respiratory and critical care medicine. 186(11):1140-9 [DOI] 10.1164/rccm.201206-0982OC. [PMID] 23024021.
2011
Altered mitochondrial regulation in quadriceps muscles of patients with COPD.
Clinical physiology and functional imaging. 31(2):124-31 [DOI] 10.1111/j.1475-097X.2010.00988.x. [PMID] 21091605.
2011
Eccentric cycle exercise in severe COPD: feasibility of application.
COPD. 8(4):270-4 [DOI] 10.3109/15412555.2011.579926. [PMID] 21728805.
2011
Exertional dyspnea in mitochondrial myopathy: clinical features and physiological mechanisms.
American journal of physiology. Regulatory, integrative and comparative physiology. 301(4):R873-84 [DOI] 10.1152/ajpregu.00001.2011. [PMID] 21813873.
2011
Mitochondria: isolation, structure and function.
The Journal of physiology. 589(Pt 18):4413-21 [DOI] 10.1113/jphysiol.2011.212712. [PMID] 21708903.
2011
Mitochondrial structure and function are disrupted by standard isolation methods.
PloS one. 6(3) [DOI] 10.1371/journal.pone.0018317. [PMID] 21512578.
2010
Mitochondrial functional impairment with aging is exaggerated in isolated mitochondria compared to permeabilized myofibers.
Aging cell. 9(6):1032-46 [DOI] 10.1111/j.1474-9726.2010.00628.x. [PMID] 20849523.
2009
Effect of changes in fat availability on exercise capacity in McArdle disease.
Archives of neurology. 66(6):762-6 [DOI] 10.1001/archneurol.2009.93. [PMID] 19506137.
2009
Fat metabolism during exercise in patients with McArdle disease.
Neurology. 72(8):718-24 [DOI] 10.1212/01.wnl.0000343002.74480.e4. [PMID] 19237700.
2008
A homoplasmic mtDNA variant can influence the phenotype of the pathogenic m.7472Cins MTTS1 mutation: are two mutations better than one?
European journal of human genetics : EJHG. 16(10):1265-74 [DOI] 10.1038/ejhg.2008.65. [PMID] 18398437.
2008
Resistance training in patients with single, large-scale deletions of mitochondrial DNA.
Brain : a journal of neurology. 131(Pt 11):2832-40 [DOI] 10.1093/brain/awn252. [PMID] 18984605.
2008
Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance.
American journal of human genetics. 82(3):652-60 [DOI] 10.1016/j.ajhg.2007.12.012. [PMID] 18304497.
2008
The mitochondrial phenotype of peripheral muscle in chronic obstructive pulmonary disease: disuse or dysfunction?
American journal of respiratory and critical care medicine. 178(10):1040-7 [DOI] 10.1164/rccm.200807-1005OC. [PMID] 18755922.
2007
The effect of training on the expression of mitochondrial biogenesis- and apoptosis-related proteins in skeletal muscle of patients with mtDNA defects.
American journal of physiology. Endocrinology and metabolism. 293(3):E672-80 [PMID] 17551003.
2006
Aerobic conditioning: an effective therapy in McArdle’s disease.
Annals of neurology. 59(6):922-8 [PMID] 16718692.
2006
Endurance training and detraining in mitochondrial myopathies due to single large-scale mtDNA deletions.
Brain : a journal of neurology. 129(Pt 12):3391-401 [PMID] 17085458.
2005
Exercise and training in mitochondrial myopathies.
Medicine and science in sports and exercise. 37(12):2094-101 [PMID] 16331135.
2004
Implications of exercise training in mtDNA defects–use it or lose it?
Biochimica et biophysica acta. 1659(2-3):221-31 [PMID] 15576055.
2003
Identification and characterization of a common set of complex I assembly intermediates in mitochondria from patients with complex I deficiency.
The Journal of biological chemistry. 278(44):43081-8 [PMID] 12941961.
2003
The spectrum of exercise tolerance in mitochondrial myopathies: a study of 40 patients.
Brain : a journal of neurology. 126(Pt 2):413-23 [PMID] 12538407.
2002
Venous oxygen levels during aerobic forearm exercise: An index of impaired oxidative metabolism in mitochondrial myopathy.
Annals of neurology. 51(1):38-44 [PMID] 11782982.
2000
Muscle phosphorus magnetic resonance spectroscopy oxidative indices correlate with physical activity.
Muscle & nerve. 23(2):175-81 [PMID] 10639607.
2000
Muscle responses to exercise in health and disease.
Neurologic clinics. 18(1):15-34 [PMID] 10658167.
2000
Recurrent myoglobinuria due to a nonsense mutation in the COX I gene of mitochondrial DNA.
Neurology. 55(5):644-9 [PMID] 10980727.
1999
Gene shifting: a novel therapy for mitochondrial myopathy.
Human molecular genetics. 8(6):1047-52 [PMID] 10332036.
1999
Short-term aerobic training response in chronic myopathies.
Muscle & nerve. 22(9):1239-43 [PMID] 10454720.
1998
Effects of aerobic training in patients with mitochondrial myopathies.
Neurology. 50(4):1055-60 [PMID] 9566394.
1998
Intracellular phosphates in inclusion body myositis–a 31P magnetic resonance spectroscopy study.
Muscle & nerve. 21(11):1523-5 [PMID] 9771678.
1997
Abnormal oxidative metabolism in exercise intolerance of undetermined origin.
Neuromuscular disorders : NMD. 7(2):99-104 [PMID] 9131650.
1997
Applications of magnetic resonance spectroscopy to diagnosis and monitoring of mitochondrial disease.
Italian journal of neurological sciences. 18(6):341-51 [PMID] 9494866.
1996
Combined aerobic training and dichloroacetate improve exercise capacity and indices of aerobic metabolism in muscle cytochrome oxidase deficiency.
Neurology. 47(2):529-34 [PMID] 8757032.

Grants

Sep 2023 ACTIVE
Countering sympathetic vasoconstriction during skeletal muscle exercise as an adjuvant therapy for DMD
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
Sep 2022 ACTIVE
Functional electrical stimulation (FES) cycling training to improve motor and cardiac functions in patients with Friedreichs Ataxia: a feasibility and efficacy study
Role: Co-Investigator
Funding: FRIEDREICHS ATAXIA RESEARCH ALLIANCE
Sep 2021 – Aug 2023
Measuring cardiopulmonary responses to the 6MWT and peak effort exercise in DMD
Role: Principal Investigator
Funding: MUSCULAR DYSTROPHY ASSO
Mar 2021 ACTIVE
CTOA
Role: Principal Investigator
Funding: UNIV OF FLORIDA
Jan 2020 ACTIVE
Use of a biomarker approach to optimize rehabilitation strategies for DMD patients
Role: Principal Investigator
Funding: EDGEWISE THERAPEUTICS
Jul 2019 ACTIVE
Impact and Interplay of Corticosteroid Regimen and Exercise Training on DMD Muscle Function
Role: Principal Investigator
Funding: US ARMY MED RES ACQUISITION
Apr 2017 – Jun 2021
OoR CTSI Institutional Matching Support
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS

Contact Details

Phones:
Business:
(352) 339-6666
Emails:
Addresses:
Business Mailing:
PO Box 100274
GAINESVILLE FL 32610