Shinichi Someya, Ph.D.
Associate Professor
Department:
Department of Physiology and Aging
Business Phone:
(352) 294-5167
Business Email:
someya@ufl.edu
About Shinichi Someya
I am a tenured Associate Professor, Director of Online Graduate Program in Gerontology, and Co-Director of Physiology Concentration in Graduate Program in Biomedical Sciences in the Department of Physiology and Aging in the College of Medicine at the University of Florida. I received my BA from the University of California, Berkeley in 1991 and received my PhD from the University of Tokyo in 2005. I then pursued my postdoctoral training in the laboratory of Dr. Tomas Prolla in the Department of Genetics at the University of Wisconsin (2005-2011). I joined the faculty in the Department of Aging and Geriatric Research at the University of Florida as a tenure-track Assistant Professor in June of 2011 and was promoted to tenured Associate Professor in July of 2016.
I have a broad background in molecular cell biology, with specific training and expertise in auditory neuroscience, aging, mitochondrial biology, and hearing loss. Currently, my research focuses on sex differences in hearing, mitochondrial function, and cochlear aging. My work employs electrophysiology, histology, biochemistry, and molecular biology to assess auditory function and cochlear pathology. We use mice as a model system because the mouse inner ear is anatomically similar to that of human and the homologies between the mouse and human genomes are well-established.
At the University of Florida, I currently direct six graduate courses: GMS 6486 Biology of Aging (fall/spring/summer), SPA5102 Auditory Anatomy and Physiology (fall), SPA6581 Anatomy and Physiology of Balance (fall), SPA6581 Auditory Pharmacology (summer), and SPA6564 Communication and Aging (spring). I also teach 5 graduate courses as a lecturer, including GMS 6893 Clinical and Translational Science Institute Student Seminar (fall), GMS 6622 Mitochondrial Biology in Aging and Disease (fall), and GMS6070 Sensory Biology (spring). In my courses, I take a student-centered and interactive approach. I encourage students to participate actively.
Related Links:
Accomplishments
2022 Exemplary Teacher
2022
·
University of Florida College of Medicine
2019 Exemplary Teacher
2019
·
University of Florida College of Medicine
2017 Exemplary Teacher
2017
·
University of Florida College of Medicine
University Term Professors for the 2017-2018 Year
2017
·
University of Florida College of Medicine
2015 William R. Jones Outstanding Mentor Awards
2015
·
Florida Education Fund
2014 Exemplary Teacher
2014
·
University of Florida College of Medicine
Certifica of Appreciation
2014
·
UF University Minority Mentorship Program
Postdoctoral Fellow Travel Award
2011
·
2011 MidWinter Meeting
Experimental Aging Research Award
2010
·
The 18th Annual NIA Summer Training Course
Travel Award
2010
·
The 39th Annual Meeting of the American Aging Association
Paul Glenn Runner up Award
2008
·
The American Aging Association
Investigator Award in Biomedical Aging Research
2007
·
UW Institute on Aging, 19th Annual Colloquium on Aging
Teaching Profile
Courses Taught
2016-2023
GMS6486 Biology of Aging
2016-2023
SPA6581 Special Clinical
2017-2023
SPA5102 Auditory Anatomy and Physiology
2020
SPA6905 Individual Study
2018-2023
SPA6564 Communication and Aging
2018-2019,2021
GMS6705 Functional Human Neuroanatomy
2017-2019,2021-2023,2023
GMS6070 Sensory and Motor Systems
2018
GMS7980 Research for Doctoral Dissertation
2015,2017
GMS6063 Mechanisms of Aging
2016
SPA3032 Fundamentals of Hearing
2015-2016
SPA7980 Research for Doctoral Dissertation
2014-2015
GMS6893 Clinical and Translational Science Seminar Series
2013-2015
GMS6417 Integrative Aging Physiology
2015
SPA7979 Advanced Research
2013-2014,2021
GMS6622 Mitochondrial Biology in Aging and Disease
2014
BMS4905 Medical Sciences Senior Research
2014
GMS7979 Advanced Research
2022-2023
GMS6905 Independent Studies in Medical Sciences
2022-2023
HSC4970 Public Health and Health Professions Senior Honors Thesis
2022-2023
GMS6701 Functional and Comparative Neuroanatomy for Professionals
2023
SPA6010 Basic Auditory Sciences
2023
GMS7795 Special Topics in Neuroscience
Research Profile
The Someya Lab studies the molecular mechanisms that underlie sex differences in hearing, mitochondrial function, and aging. Our work employs molecular genetics tools to identify the genes and pathways involved in aging and mitochondrial dysfunction. These studies are complemented by the use of electrophysiology and histology to assess hearing function and cochlear pathology. We use mice as a model system because the mouse inner ear is anatomically similar to that of human and the homologies between the mouse and human genomes are well-established.
http://someyalab.aging.ufl.edu/about-someya-lab/
Open Researcher and Contributor ID (ORCID)
0000-0001-9895-6227
Areas of Interest
- Aging
- Impact of hearing loss
- Mitochondria
- Sex Differences
Publications
2023
Disease correction in mucopolysaccharidosis type IIIB mice by intraparenchymal or cisternal delivery of a capsid modified AAV8 codon-optimized NAGLU vector.
Human molecular genetics.
32(3):417-430
[DOI] 10.1093/hmg/ddac209.
[PMID] 35997776.
2023
Sex differences in body composition, voluntary wheel running activity, balance performance, and auditory function in CBA/CaJ mice across the lifespan
Hearing Research.
428
[DOI] 10.1016/j.heares.2022.108684.
2023
Taurine, Coenzyme Q10, and Hydrogen Water Prevents Germanium Dioxide-Induced Mitochondrial Dysfunction and Associated Sensorineural Hearing Loss in mouse.
Hearing research.
428
[DOI] 10.1016/j.heares.2022.108678.
[PMID] 36577362.
2023
The roles of NADPH and isocitrate dehydrogenase in cochlear mitochondrial antioxidant defense and aging
Hearing Research.
427
[DOI] 10.1016/j.heares.2022.108659.
2021
Cochlear detoxification: Role of alpha class glutathione transferases in protection against oxidative lipid damage, ototoxicity, and cochlear aging.
Hearing research.
402
[DOI] 10.1016/j.heares.2020.108002.
[PMID] 32600853.
2021
Roles of Bak and Sirt3 in Paraquat-Induced Cochlear Hair Cell Damage.
Neurotoxicity research.
39(4):1227-1237
[DOI] 10.1007/s12640-021-00366-6.
[PMID] 33900547.
2020
“Passenger gene” problem in transgenic C57BL/6 mice used in hearing research.
Neuroscience research.
158:6-15
[DOI] 10.1016/j.neures.2019.10.007.
[PMID] 31622631.
2020
Effects of Gsta4 deficiency on age-related cochlear pathology and hearing loss in mice.
Experimental gerontology.
133
[DOI] 10.1016/j.exger.2020.110872.
[PMID] 32044382.
2020
Innovations in Geroscience to enhance mobility in older adults.
Experimental gerontology.
142
[DOI] 10.1016/j.exger.2020.111123.
[PMID] 33191210.
2020
Txn2 haplodeficiency does not affect cochlear antioxidant defenses or accelerate the progression of cochlear cell loss or hearing loss across the lifespan.
Experimental gerontology.
141
[DOI] 10.1016/j.exger.2020.111078.
[PMID] 32866605.
2019
A Novel Mouse Model of MYO7A USH1B Reveals Auditory and Visual System Haploinsufficiencies.
Frontiers in neuroscience.
13
[DOI] 10.3389/fnins.2019.01255.
[PMID] 31824252.
2019
GSTA4 mediates reduction of cisplatin ototoxicity in female mice
Nature Communications.
10(1)
[DOI] 10.1038/s41467-019-12073-0.
[PMID] 31515474.
2019
Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice.
Experimental gerontology.
125
[DOI] 10.1016/j.exger.2019.110675.
[PMID] 31344454.
2018
Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice
Scientific Reports.
8(1)
[DOI] 10.1038/s41598-018-23436-w.
[PMID] 29567975.
2017
Corrigendum: Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance.
Nature communications.
8
[DOI] 10.1038/ncomms16143.
[PMID] 31305776.
2017
Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice
PLOS ONE.
12(2)
[DOI] 10.1371/journal.pone.0171159.
[PMID] 28158260.
2017
G6pd Deficiency Does Not Affect the Cytosolic Glutathione or Thioredoxin Antioxidant Defense in Mouse Cochlea
The Journal of Neuroscience.
37(23):5770-5781
[DOI] 10.1523/jneurosci.0519-17.2017.
2017
G6pd Deficiency Does Not Affect the Cytosolic Glutathione or Thioredoxin Antioxidant Defense in Mouse Cochlea
The Journal of Neuroscience.
37(23):5770-5781
[DOI] 10.1523/jneurosci.0519-17.2017.
2017
GSR is not essential for the maintenance of antioxidant defenses in mouse cochlea: Possible role of the thioredoxin system as a functional backup for GSR
PLOS ONE.
12(7)
[DOI] 10.1371/journal.pone.0180817.
[PMID] 28686716.
2017
Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea.
Neuroscience.
361:179-191
[DOI] 10.1016/j.neuroscience.2017.08.015.
[PMID] 28818524.
2017
Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance.
Nature communications.
8
[DOI] 10.1038/ncomms14477.
[PMID] 28205519.
2017
Studies on the regulatory mechanism of isocitrate dehydrogenase 2 using acetylation mimics
Scientific Reports.
7(1)
[DOI] 10.1038/s41598-017-10337-7.
[PMID] 28852116.
2016
Effects of Long-Term Exercise on Age-Related Hearing Loss in Mice
The Journal of Neuroscience.
36(44):11308-11319
[DOI] 10.1523/jneurosci.2493-16.2016.
2016
GLAST Deficiency in Mice Exacerbates Gap Detection Deficits in a Model of Salicylate-Induced Tinnitus.
Frontiers in behavioral neuroscience.
10
[DOI] 10.3389/fnbeh.2016.00158.
[PMID] 27582696.
2016
Intraoperative hemidiaphragm electrical stimulation reduces oxidative stress and upregulates autophagy in surgery patients undergoing mechanical ventilation: exploratory study.
Journal of translational medicine.
14(1)
[PMID] 27784315.
2016
Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice
Neurobiology of Aging.
43:58-71
[DOI] 10.1016/j.neurobiolaging.2016.03.023.
[PMID] 27255815.
2015
A conserved transcriptional signature of delayed aging and reduced disease vulnerability is partially mediated by SIRT3.
PloS one.
10(4)
[DOI] 10.1371/journal.pone.0120738.
[PMID] 25830335.
2015
Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life.
PloS one.
10(5)
[DOI] 10.1371/journal.pone.0126644.
[PMID] 25978367.
2015
Successful aging: Advancing the science of physical independence in older adults.
Ageing research reviews.
24(Pt B):304-27
[DOI] 10.1016/j.arr.2015.09.005.
[PMID] 26462882.
2014
The Role of Mitochondrial Isocitrate Dehydrogenase 2 in Age-Related Hearing Loss in Mice
Gerontologist.
54(2)
2014
The Roles of Glutathione Reductase in Age-Related Hearing Loss in Mice
Gerontologist.
54(2)
2013
Addition of exogenous NAD+ prevents mefloquine-induced neuroaxonal and hair cell degeneration through reduction of caspase-3-mediated apoptosis in cochlear organotypic cultures.
PloS one.
8(11)
[DOI] 10.1371/journal.pone.0079817.
[PMID] 24223197.
2013
Current concepts in age-related hearing loss: epidemiology and mechanistic pathways.
Hearing research.
303:30-8
[DOI] 10.1016/j.heares.2013.01.021.
[PMID] 23422312.
2013
Maintaining good hearing: calorie restriction, Sirt3, and glutathione.
Experimental gerontology.
48(10):1091-5
[DOI] 10.1016/j.exger.2013.02.014.
[PMID] 23454634.
2013
Mouse models of age-related mitochondrial neurosensory hearing loss.
Molecular and cellular neurosciences.
55:95-100
[DOI] 10.1016/j.mcn.2012.07.004.
[PMID] 22820179.
2013
Ototoxic Model of Oxaliplatin and Protection from Nicotinamide Adenine Dinucleotide.
Journal of otology.
8(1):63-71
[PMID] 25419212.
2012
Influence of viral vector-mediated delivery of superoxide dismutase and catalase to the hippocampus on spatial learning and memory during aging.
Antioxidants & redox signaling.
16(4):339-50
[DOI] 10.1089/ars.2011.4054.
[PMID] 21942371.
2012
OTOTOXIC EFFECTS OF CARBOPLATIN IN ORGANOTYPIC CULTURES IN CHINCHILLAS AND RATS.
Journal of otology.
7(2):92-101
[PMID] 25593588.
2011
Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction.
Molecular cell.
41(2):139-49
[DOI] 10.1016/j.molcel.2011.01.002.
[PMID] 21255725.
2010
Effects of caloric restriction on age-related hearing loss in rodents and rhesus monkeys.
Current aging science.
3(1):20-5
[PMID] 20298166.
2010
Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice.
PloS one.
5(7)
[DOI] 10.1371/journal.pone.0011468.
[PMID] 20628647.
2010
Mitochondrial oxidative damage and apoptosis in age-related hearing loss.
Mechanisms of ageing and development.
131(7-8):480-6
[DOI] 10.1016/j.mad.2010.04.006.
[PMID] 20434479.
2010
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction.
Cell.
143(5):802-12
[DOI] 10.1016/j.cell.2010.10.002.
[PMID] 21094524.
2009
Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis.
Proceedings of the National Academy of Sciences of the United States of America.
106(46):19432-7
[DOI] 10.1073/pnas.0908786106.
[PMID] 19901338.
2008
The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase gamma.
Neurobiology of aging.
29(7):1080-92
[PMID] 17363114.
2007
Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis.
Neurobiology of aging.
28(10):1613-22
[PMID] 16890326.
2007
Genes encoding mitochondrial respiratory chain components are profoundly down-regulated with aging in the cochlea of DBA/2J mice.
Brain research.
1182:26-33
[PMID] 17964557.
2007
Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss.
Hearing research.
226(1-2):185-93
[PMID] 16870370.
2005
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging.
Science (New York, N.Y.).
309(5733):481-4
[PMID] 16020738.
1985
Depolarizing afterpotentials in myelinated axons of mammalian spinal cord.
Neuroscience.
15(1):1-12
[PMID] 4010930.
1972
Studies on tubercle bacillus infection in germ-free mice.
Journal of the Reticuloendothelial Society.
12(5):545-63
[PMID] 4676283.
Grants
Jun 2022
ACTIVE
University of Florida Claude D. Pepper Older Americans Independence Center
Role: Other
Funding: NATL INST OF HLTH NIA
Jul 2020
ACTIVE
Molecular Mechanisms of Hair Bundle Development and Maintenance
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCD
Jul 2018
ACTIVE
Estrogen and cognition over the lifespan
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Jan 2018
ACTIVE
SMK-1, a novel, conserved nuclear activator of DAF-16/FOXO tumor suppressor
Role: Faculty
Funding: AMER CANCER SOC
Aug 2017
ACTIVE
Optimizing AAV Vectors for Central Nervous System transduction
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Apr 2015
– Mar 2022
Cochlear Detoxification System
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCD
Apr 2013
– Jun 2019
Mitochondrial thioredoxin, caloric restriction, and age-related hearing loss
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCD
Education
PhD, Applied Biological Chemistry
2005
·
University of Tokyo
Bachelor of Arts, Molecular Science and Cell Biology
1991
·
University of California, Berkeley
Contact Details
Phones:
- Business:
- (352) 294-5167
Emails:
- Business:
- someya@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100143
1600 SW ARCHER RD
GAINESVILLE FL 32610 - Business Street:
-
M2-230
1600 SW Archer Rd
Gainesville FL 32610