Robert Mankowski, Ph.D.
Assistant Professor
Department:
Department of Physiology and Aging
Business Phone:
(352) 294-5055
Business Email:
r.mankowski@ufl.edu
About Robert Mankowski
Dr. Robert Mankowski is an Assistant Professor at the Department of Aging and Geriatric Research. He obtained his PhD in Exercise Physiology at the Erasmus University Medical Center in Rotterdam, The Netherlands. His translational and team-science research is focused on preserving physical and cardiovascular function in older age. His research spans from investigating the effects of nutritional and exercise interventions on physical and cardiovascular function in moderately functioning older adults, to better understanding the epidemiology and pathobiology of poor long-term physical and cognitive outcomes in older survivors (including race and sex differences) of critical illness, especially sepsis. He aims to translate effective exercise (institution-based and remotely delivered) and nutritional interventions from moderately functioning older adults to poorly functioning older survivors of critical illness. His ultimate goal is to customize exercise and nutritional interventions in populations at risk of frailty, and thus improve quality of life and expand the health span.
Teaching Profile
Courses Taught
2017-2023
GMS6717 Healthy Aging in The New Millennium
2018-2023
GMS6483 Theories of Aging
2019
GMS6893 Clinical and Translational Science Seminar Series
2023
GMS6484 Geriatric and Age Related Diseases
Publications
Academic Articles
2024
Exercise training to preserve vitality capacity in ageing.
Experimental physiology.
[DOI] 10.1113/EP091731.
[PMID] 39504077.
2024
Gut mycobiome dysbiosis after sepsis and trauma.
Critical care (London, England).
28(1)
[DOI] 10.1186/s13054-023-04780-4.
[PMID] 38212826.
2024
Home-Based Digital Exercise Training Program to Improve Physical Function of Older Sepsis Survivors: Protocol of the HEAL Sepsis Randomized Clinical Trial.
JMIR research protocols.
13
[DOI] 10.2196/60270.
[PMID] 39418096.
2024
Iron and cancer: overview of the evidence from population-based studies.
Frontiers in oncology.
14
[DOI] 10.3389/fonc.2024.1393195.
[PMID] 39246326.
2024
Iron homeostasis in older adults: balancing nutritional requirements and health risks.
The journal of nutrition, health & aging.
28(5)
[DOI] 10.1016/j.jnha.2024.100212.
[PMID] 38489995.
2024
Mitochondrial quality control measures, systemic inflammation, and lower-limb muscle power in older adults: a PROMPT secondary analysis.
The journal of nutrition, health & aging.
28(12)
[DOI] 10.1016/j.jnha.2024.100408.
[PMID] 39504617.
2024
MoTrPAC Animal Aerobic Exercise Protocol and Biorepository: A Novel Resource for Uncovering Systemic Adaptations to Aerobic Exercise and Extending Healthspan.
Function (Oxford, England).
5(5)
[DOI] 10.1093/function/zqae040.
[PMID] 39251389.
2024
Persistence and Sexual Dimorphism of Gut Dysbiosis and Pathobiome after Sepsis and Trauma.
Annals of surgery.
280(3):491-503
[DOI] 10.1097/SLA.0000000000006385.
[PMID] 38864230.
2024
Severe trauma leads to sustained muscle loss, induced frailty, and distinct temporal changes in myokine and chemokine profiles of older patients.
Surgery.
176(5):1516-1524
[DOI] 10.1016/j.surg.2024.07.031.
[PMID] 39179433.
2023
Effects of Curcumin C3 Complex® on Physical Function in Moderately Functioning Older Adults with Low-Grade Inflammation – A Pilot Trial.
The Journal of frailty & aging.
12(2):143-149
[DOI] 10.14283/jfa.2022.47.
[PMID] 36946712.
2023
Intraoperative Hemi-Diaphragm Electrical Stimulation Demonstrates Attenuated Mitochondrial Function without Change in Oxidative Stress in Cardiothoracic Surgery Patients.
Antioxidants (Basel, Switzerland).
12(5)
[DOI] 10.3390/antiox12051009.
[PMID] 37237876.
2023
Low muscle mass is associated with a higher risk of all-cause and cardiovascular disease-specific mortality in cancer survivors.
Nutrition (Burbank, Los Angeles County, Calif.).
107
[DOI] 10.1016/j.nut.2022.111934.
[PMID] 36563433.
2023
Relationship between Mitochondrial Quality Control Markers, Lower Extremity Tissue Composition, and Physical Performance in Physically Inactive Older Adults.
Cells.
12(1)
[DOI] 10.3390/cells12010183.
[PMID] 36611976.
2023
Sex differences in frailty among older adults.
Experimental gerontology.
184
[DOI] 10.1016/j.exger.2023.112333.
[PMID] 37993077.
2023
The persistent inflammation, immunosuppression, and catabolism syndrome 10 years later.
The journal of trauma and acute care surgery.
95(5):790-799
[DOI] 10.1097/TA.0000000000004087.
[PMID] 37561664.
2023
Understanding Post-Sepsis Syndrome: How Can Clinicians Help?
Infection and drug resistance.
16:6493-6511
[DOI] 10.2147/IDR.S390947.
[PMID] 37795206.
2022
Older Adults Demonstrate Biomarker Evidence of the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS) After Sepsis.
The journals of gerontology. Series A, Biological sciences and medical sciences.
77(1):188-196
[DOI] 10.1093/gerona/glab080.
[PMID] 33721883.
2022
Sex differences associate with late microbiome alterations after murine surgical sepsis.
The journal of trauma and acute care surgery.
93(2):137-146
[DOI] 10.1097/TA.0000000000003599.
[PMID] 35324554.
2022
Translational research on aging and adaptations to exercise.
Experimental gerontology.
166
[DOI] 10.1016/j.exger.2022.111872.
[PMID] 35803083.
2022
Vitamin D Supplementation Is Associated with a Reduction in Self-Reported Falls among Older Adults with Previous Fall History – Feasibility Study.
The Journal of frailty & aging.
11(2):224-230
[DOI] 10.14283/jfa.2021.46.
[PMID] 35441201.
2021
Erratum to “Impact of COVID-19 on Future Ischemic Stroke Incidence” [eNeurologicalSci, 22C (2021) 100325].
eNeurologicalSci.
23
[DOI] 10.1016/j.ensci.2021.100342.
[PMID] 33937535.
2021
Impact of COVID-19 on Future Ischemic Stroke Incidence.
eNeurologicalSci.
22
[DOI] 10.1016/j.ensci.2021.100325.
[PMID] 33553699.
2021
Novel insights on the role of spexin as a biomarker of obesity and related cardiometabolic disease.
International journal of obesity (2005).
45(10):2169-2178
[DOI] 10.1038/s41366-021-00906-2.
[PMID] 34253845.
2021
Pathophysiology and Treatment Strategies of Acute Myopathy and Muscle Wasting after Sepsis.
Journal of clinical medicine.
10(9)
[DOI] 10.3390/jcm10091874.
[PMID] 33926035.
2021
Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial.
Experimental gerontology.
143
[DOI] 10.1016/j.exger.2020.111111.
[PMID] 33068691.
2021
Sepsis-Induced Myopathy and Gut Microbiome Dysbiosis: Mechanistic Links and Therapeutic Targets.
Shock (Augusta, Ga.).
[DOI] 10.1097/SHK.0000000000001843.
[PMID] 34726875.
2021
Septic Stability? Gut Microbiota in Young Adult Mice Maintains Overall Stability After Sepsis Compared to Old Adult Mice.
Shock (Augusta, Ga.).
55(4):519-525
[DOI] 10.1097/SHK.0000000000001648.
[PMID] 32826817.
2021
The Effect of Aging Physiology on Critical Care.
Critical care clinics.
37(1):135-150
[DOI] 10.1016/j.ccc.2020.08.006.
[PMID] 33190766.
2021
Vascular dysfunction as a potential culprit of sarcopenia.
Experimental gerontology.
145
[DOI] 10.1016/j.exger.2020.111220.
[PMID] 33373710.
2020
Altered Expression of Mitoferrin and Frataxin, Larger Labile Iron Pool and Greater Mitochondrial DNA Damage in the Skeletal Muscle of Older Adults.
Cells.
9(12)
[DOI] 10.3390/cells9122579.
[PMID] 33276460.
2020
Higher dose of resveratrol elevated cardiovascular disease risk biomarker levels in overweight older adults – A pilot study.
Experimental gerontology.
131
[DOI] 10.1016/j.exger.2019.110821.
[PMID] 31891746.
2020
Innovations in Geroscience to enhance mobility in older adults.
Experimental gerontology.
142
[DOI] 10.1016/j.exger.2020.111123.
[PMID] 33191210.
2020
Nicotinamide riboside-A missing piece in the puzzle of exercise therapy for older adults?
Experimental gerontology.
137
[DOI] 10.1016/j.exger.2020.110972.
[PMID] 32450270.
2020
Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long-Term Survival.
Journal of the American Geriatrics Society.
68(9):1962-1969
[DOI] 10.1111/jgs.16435.
[PMID] 32294254.
2020
The relationship between interleukin-6 levels and physical performance in mobility-limited older adults with chronic low-grade inflammation: The ENRGISE Pilot study.
Archives of gerontology and geriatrics.
90
[DOI] 10.1016/j.archger.2020.104131.
[PMID] 32554219.
2019
Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle.
Cells.
8(12)
[DOI] 10.3390/cells8121525.
[PMID] 31783583.
2019
Exercise is Medicine as a Vital Sign: Challenges and Opportunities.
Translational journal of the American College of Sports Medicine.
4(1):1-7
[PMID] 30828640.
2019
Long-term impact of sepsis on cardiovascular health.
Intensive care medicine.
45(1):78-81
[DOI] 10.1007/s00134-018-5173-1.
[PMID] 29740669.
2019
Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors.
Critical care (London, England).
23(1)
[DOI] 10.1186/s13054-019-2505-7.
[PMID] 31234943.
2019
The Development of Chronic Critical Illness Determines Physical Function, Quality of Life, and Long-Term Survival Among Early Survivors of Sepsis in Surgical ICUs.
Critical care medicine.
47(4):566-573
[DOI] 10.1097/CCM.0000000000003655.
[PMID] 30664526.
2018
Effects of 90 Days of Resveratrol Supplementation on Cognitive Function in Elders: A Pilot Study.
Journal of alternative and complementary medicine (New York, N.Y.).
24(7):725-732
[DOI] 10.1089/acm.2017.0398.
[PMID] 29583015.
2018
Effects of Fermented Papaya Preparation (FPP) on Safety Outcomes in Older Adults – A Short Report of a Placebo-Controlled Clinical Trial.
The Journal of frailty & aging.
7(2):142-146
[DOI] 10.14283/jfa.2018.6.
[PMID] 29741201.
2018
Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis.
Ageing research reviews.
46:42-59
[DOI] 10.1016/j.arr.2018.05.004.
[PMID] 29803716.
2018
Mitochondrial quality control mechanisms as molecular targets in cardiac ageing.
Nature reviews. Cardiology.
15(9):543-554
[DOI] 10.1038/s41569-018-0059-z.
[PMID] 30042431.
2018
Nutrition and Exercise in Sarcopenia.
Current protein & peptide science.
19(7):649-667
[DOI] 10.2174/1389203717666161227144349.
[PMID] 28029078.
2017
Device-Measured Physical Activity As a Predictor of Disability in Mobility-Limited Older Adults.
Journal of the American Geriatrics Society.
65(10):2251-2256
[DOI] 10.1111/jgs.15037.
[PMID] 28799216.
2017
Heart-Rate Variability Threshold as an Alternative for Spiro-Ergometry Testing: A Validation Study.
Journal of strength and conditioning research.
31(2):474-479
[DOI] 10.1519/JSC.0000000000001502.
[PMID] 27391041.
2017
Management of an LCHADD Patient During Pregnancy and High Intensity Exercise.
JIMD reports.
32:95-100
[DOI] 10.1007/8904_2016_561.
[PMID] 27334895.
2017
Oxygen delivery is not a limiting factor during post-exercise recovery in healthy young adults.
Journal of exercise science and fitness.
15(1):43-47
[DOI] 10.1016/j.jesf.2017.07.001.
[PMID] 29541131.
2017
Resveratrol and exercise to treat functional limitations in late life: design of a randomized controlled trial.
Contemporary clinical trials communications.
6:58-63
[DOI] 10.1016/j.conctc.2017.03.002.
[PMID] 28944303.
2016
Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: a feasibility study.
European journal of medical research.
21
[DOI] 10.1186/s40001-015-0194-5.
[PMID] 26744210.
2016
Intraoperative hemidiaphragm electrical stimulation reduces oxidative stress and upregulates autophagy in surgery patients undergoing mechanical ventilation: exploratory study.
Journal of translational medicine.
14(1)
[PMID] 27784315.
2015
Dietary Antioxidants as Modifiers of Physiologic Adaptations to Exercise.
Medicine and science in sports and exercise.
47(9):1857-68
[DOI] 10.1249/MSS.0000000000000620.
[PMID] 25606815.
2015
Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations–The LIFE Study.
Experimental gerontology.
70:32-6
[DOI] 10.1016/j.exger.2015.06.018.
[PMID] 26130060.
2015
Successful aging: Advancing the science of physical independence in older adults.
Ageing research reviews.
24(Pt B):304-27
[DOI] 10.1016/j.arr.2015.09.005.
[PMID] 26462882.
2010
Effects of long-term exposure to air pollution on respiratory function and physical efficiency of pre-adolescent children.
European journal of medical research.
15 Suppl 2(Suppl 2):224-8
[PMID] 21147656.
Grants
Aug 2023
– Mar 2024
Understanding pathology of sepsis-induced physical disability for future precision medicine
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Mar 2022
ACTIVE
Home-based digital exercise training program to improve physical function of older sepsis survivorsHEAL Sepsis Trial
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Sep 2019
– Feb 2023
Nicotinamide riboside as an Enhancer of Exercise Therapy in hypertensive older adults: The NEET Trial
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Jul 2018
– Jun 2022
Cardiac Dysfunction in Older Sepsis Survivors
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION
Jul 2017
– May 2022
The effect of intermittent hemidiaphragm stimulation during surgery on mitochondrial function, single fiber contractile force and catabolic pathways in humans
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Apr 2017
– Mar 2022
University of Florida Claude D. Pepper Older Americans Independence Center (OAIC)
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Education
PhD in Exercise Physiology
2010-2015
·
The Erasmus University Medical Center, Rotterdam, The Netherlands
Master of Science in Physical Therapy
2008-2010
·
The Jerzy Kukuczka Academy of Physical Education, Katowice, Poland
Bachelor of Science in Physical Therapy
2005-2008
·
The Jerzy Kukuczka Academy of Physical Education, Katowice, Poland
Contact Details
Phones:
- Business:
- (352) 294-5055
Emails:
- Business:
- r.mankowski@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100107
GAINESVILLE FL 32610 - Business Street:
-
2004 Mowry Raod
GAINESVILLE FL 32611