Shi Jin

Shi Jin, Ph.D.

LECTURER

Department: Department of Physiology and Aging
Business Phone: (352) 273-9523
Business Email: shijin2015uf@ufl.edu

About Shi Jin

Currently, Shi Jin is a lecturer of medical physiology at The University of Florida in the Department of Physiology and Aging. In 1998, Shi received his Bachelor of Clinical Medicine (Medical Degree) from Shanghai Medical College, Fudan University, China. In 2007 at The University of Tennessee Health Science Center (UTHSC), Shi obtained his PhD degree in physiology under the mentorship of Dr. Leonard R. Johnson. Shi had working experiences related to medicine including clinical service, medical education, and biomedical research for about two decades. With his passion for medical research and education, for more than fifteen years, Shi has been trained as a gastrointestinal (GI) physiologist at different institutions, including The University of Tennessee, Johns Hopkins University, and The University of Florida, and he also loves to share his knowledge and learning experiences with his students. Shi’s teaching interests focus on basic medical sciences, including medical physiology and pathophysiology, human embryology and developmental biology, histology and histopathology.

Accomplishments

Exemplary Teacher
2023 · College of Medicine, University of Florida
Daniel & Dorothy K. Gerwin Scholarship
2006 · Department of Physiology, School of Medicine, University of Tennessee
J. Paul Quigley Memorial Scholarship
2004 · Department of Physiology, School of Medicine, University of Tennessee

Teaching Profile

Courses Taught
2022-2024
GMS6415 Fundamentals of Gastrointestinal Physiology
2022-2024
GMS6400C Principles of Physiology
2022-2024
GMS6479 Medical Gastrointestinal Physiology
2022-2023
PAS5025 Human Physiology
2023-2024
GMS6419 Medical Endocrinology and Reproduction
2023-2024
GMS6405 Fundamentals of Endocrine Physiology
2023
DEN5120C Physiology
2024
BMS3521 Human Physiology in Translation

Research Profile

Shi’s research interests focus on GI physiology and experimental gastroenterology, which include (1) molecular mechanisms of apoptosis in intestinal epithelial cells (2) mechanisms for trafficking of proteins involved in sodium absorption in the GI tract, such as NHE3 (sodium hydrogen exchanger 3) (3) molecular mechanisms for inflammation-associated bowel diseases.

Open Researcher and Contributor ID (ORCID)

0000-0003-0177-5716

Areas of Interest
  • Cell signaling pathways
  • Gastrointestinal Physiology
  • Protein-protein interactions
  • inflammatory bowel disease
  • membrane protein

Publications

2024
Calcium/calcimimetic via calcium-sensing receptor ameliorates cholera toxin-induced secretory diarrhea in mice.
World journal of gastroenterology. 30(3):268-279 [DOI] 10.3748/wjg.v30.i3.268. [PMID] 38314127.
2023
Ca2+ fortified oral rehydration solution is effective in reducing diarrhea morbidity in cholera toxin-pretreated mice.
Research square. [DOI] 10.21203/rs.3.rs-3482753/v1. [PMID] 37961244.
2018
Inflammation in the Tumor Microenvironment.
Journal of immunology research. 2018:1965847-2 [DOI] 10.1155/2018/1965847. [PMID] 30035130.
2017
Calcium-Sensing Receptor Regulation of Tight Junction Integrity and Intestinal Barrier: Role of Nutrients
Gastroenterology. 152(5) [DOI] 10.1016/s0016-5085(17)32656-2.
2017
The Pathogenic Role of NLRP3 Inflammasome Activation in Inflammatory Bowel Diseases of Both Mice and Humans.
Journal of Crohn's & colitis. 11(6):737-750 [DOI] 10.1093/ecco-jcc/jjw219. [PMID] 27993998.
2016
Activation of calcium-sensing receptor in the gut inhibits enterotoxin-induced secretion and bacteria-induced inflammation in rodents and reduces infectious diarrheas in children.
Journal of Pediatric Gastroenterology & Nutrition. 63(Supplement 2):S2-S2
2015
Clc-5-deficient mice, a novel murine model for investigating the role of gut microbiota in obesity and metabolic syndrome
Diabetologia. 58(Suppl 1):S112-S112
2014
Loss of regulatory intestinal dendritic cell subsets during gut inflammation in humans and mice
The Journal of Immunology. 192(1 Supplement):68.14-68.14
2014
NHERF2/NHERF3 protein heterodimerization and macrocomplex formation are required for the inhibition of NHE3 activity by carbachol.
The Journal of biological chemistry. 289(29):20039-53 [DOI] 10.1074/jbc.M114.562413. [PMID] 24867958.
2014
The mechanism by which MEK/ERK regulates JNK and p38 activity in polyamine depleted IEC-6 cells during apoptosis.
Apoptosis : an international journal on programmed cell death. 19(3):467-79 [DOI] 10.1007/s10495-013-0944-1. [PMID] 24253595.
2014
The role of IL-10 in differentiation of regulatory dendritic cells and macrophages in the gut.
Immunology (WILEY-BLACKWELL). 143(s2):67-67
2013
NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells.
The Journal of biological chemistry. 288(23):16960-16974 [DOI] 10.1074/jbc.M113.470799. [PMID] 23612977.
2013
Sa1790 Spontaneous and Persistent Activation of NLRP3/NALP3 Inflammasome Plays a Critical Pathological Role in Colitis of IL-10 Deficient Mice
Gastroenterology. 144(5):S-307 [DOI] 10.1016/s0016-5085(13)61101-4.
2012
African Folk Treatment, Garcinia Buchananii, is an Effective Treatment for Toxin-induced Diarrhea
Annual Biomedical Research Conference for Minority Students (ABRCMS) . (No. C063)
2012
Role of p53 in Anticancer Drug Treatment- and Radiation-Induced Injury in Normal Small Intestine.
Cancer biology & medicine. 9(1):1-8 [DOI] 10.3969/j.issn.2095-3941.2012.01.001. [PMID] 23691447.
2011
Chloride channel (Clc)-5 is necessary for exocytic trafficking of Na+/H+ exchanger 3 (NHE3).
The Journal of biological chemistry. 286(26):22833-45 [DOI] 10.1074/jbc.M111.224998. [PMID] 21561868.
2011
Regulation of JNK activity in the apoptotic response of intestinal epithelial cells.
American journal of physiology. Gastrointestinal and liver physiology. 300(5):G761-70 [DOI] 10.1152/ajpgi.00405.2010. [PMID] 21350193.
2009
Caspase‐8 activation requires functional mitochondria in camptothecin‐induced apoptosis in intestinal epithelial cells
The FASEB Journal. 23(S1) [DOI] 10.1096/fasebj.23.1_supplement.618.8.
2008
TNF-alpha/cycloheximide-induced apoptosis in intestinal epithelial cells requires Rac1-regulated reactive oxygen species.
American journal of physiology. Gastrointestinal and liver physiology. 294(4):G928-37 [DOI] 10.1152/ajpgi.00219.2007. [PMID] 18218673.
2007
Rac1‐dependent ROS production mediates TNF‐alpha‐induced apoptosis in intestinal epithelial cells
The FASEB Journal. 21(6) [DOI] 10.1096/fasebj.21.6.a1345-a.
2007
Role of myosin regulatory light chain and Rac1 in the migration of polyamine-depleted intestinal epithelial cells.
American journal of physiology. Gastrointestinal and liver physiology. 292(4):G983-95 [PMID] 17170026.
2006
Rac1 mediates intestinal epithelial cell apoptosis via JNK.
American journal of physiology. Gastrointestinal and liver physiology. 291(6):G1137-47 [PMID] 16798728.
2000
Effects and Binding Sites of Glycyrrhetinic Acid and Glycyrrhizin on isolated rat hepatocyte membrane
Fudan University Journal of Medical Science (Former Journal of Shanghai Medical University). 27(4):270-273

Education

PhD in Physiology
2007 · The University of Tennessee Health Science Center, USA
Bachelor of Clinical Medicine (Medical Degree)
1998 · Shanghai Medical College, Fudan University, China

Contact Details

Phones:
Business:
(352) 273-9523
Emails:
Addresses:
Business Mailing:
University of Florida
Box 100274
Department of Physiology and Aging
GAINESVILLE FL 326100274
Business Street:
1345 Center Drive, Room CG-20F
GAINESVILLE FL 32610