Erwin Kristobal Gudenschwager Basso

Erwin Kristobal Gudenschwager Basso,

Research Assistant Professor

Department: Department of Physiology and Aging
Business Phone: (352) 294-5064
Business Email:

About Erwin Kristobal Gudenschwager Basso

I am currently serving as a Research Assistant professor in the Department of Physiology and Aging, College of Medicine. My academic training began with the completion of my Doctor of Veterinary Medicine degree from Universidad Austral, Valdivia, Chile. Building upon my foundation in biomedical research, I pursued a Ph.D. in Biomedical and Veterinary Sciences at Virginia Tech, where I studied angiogenesis signaling on placental development and skin tumors. Following my doctoral studies, I started a rewarding postdoctoral training focusing into the mechanisms of traumatic brain injury (TBI). My investigations utilized murine models of controlled cortical impact, repetitive mild TBI, and post-traumatic epilepsy (PTE). I sought to unravel the complexities of TBI and shed light on the role of the immune system in the aftermath of such injuries. The overarching objective of my research endeavors has been to identify strategies that mitigate secondary injury and promote enhanced recovery following TBI. I am also interested on study the early brain changes that predispose individuals to the development of post-traumatic epilepsy. Furthermore, I am intrigued by the relationship between TBI and sleep disturbances, as well as the impact of TBI on circadian rhythms. Exploring these interconnected aspects will contribute to our understanding of the multifaceted nature of TBI and facilitate the development of novel therapeutic interventions. By virtue of my diverse academic background and research experience, I am committed to advancing the frontiers of knowledge in the field of traumatic brain injury and its associated sequelae. The opportunity to join the Department of Physiology and Aging at the University of Florida presents a unique platform to explore these research avenues and make significant contributions to the scientific community.

Research Profile

Open Researcher and Contributor ID (ORCID)


Areas of Interest
  • Circadian Clock
  • Microglia
  • Neuroimmune interactions in Neurodegenerative diseases
  • Neuroimmunology
  • Stroke
  • traumatic brain injury


Immunoregulatory and neutrophil-like monocyte subsets with distinct single-cell transcriptomic signatures emerge following brain injury.
Journal of neuroinflammation. 21(1) [DOI] 10.1186/s12974-024-03032-8. [PMID] 38310257.
Lifelong Chronic Sleep Disruption in a Mouse Model of Traumatic Brain Injury.
Neurotrauma reports. 5(1):61-73 [DOI] 10.1089/neur.2023.0107. [PMID] 38288298.
A team science approach for the preclinical and clinical characterization and biomarker development for post‐traumatic epilepsy
Epilepsia Open. [DOI] 10.1002/epi4.12745.
Atypical Neurogenesis, Astrogliosis, and Excessive Hilar Interneuron Loss Are Associated with the Development of Post-Traumatic Epilepsy
Cells. 12(9) [DOI] 10.3390/cells12091248. [PMID] 37174647.
Endothelial deletion of EPH receptor A4 alters single-cell profile and Tie2/Akap12 signaling to preserve blood–brain barrier integrity
Proceedings of the National Academy of Sciences. 120(41) [DOI] 10.1073/pnas.2204700120. [PMID] 37796990.
Sleep Disruption in a Mouse Model of Chronic Traumatic Brain Injury.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2023.11.10.566553. [PMID] 38014315.
Characterization of the Expression of Angiogenic Factors in Cutaneous Squamous Cell Carcinoma of Domestic Cats
Veterinary Sciences. 9(7) [DOI] 10.3390/vetsci9070375. [PMID] 35878392.
Monocyte proinflammatory phenotypic control by ephrin type A receptor 4 mediates neural tissue damage
JCI Insight. 7(15) [DOI] 10.1172/jci.insight.156319. [PMID] 35737458.
Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury.
Frontiers in molecular neuroscience. 15 [DOI] 10.3389/fnmol.2022.852243. [PMID] 35283725.
Conditional Deletion of EphA4 on Cx3cr1-Expressing Microglia Fails to Influence Histopathological Outcome and Blood Brain Barrier Disruption Following Brain Injury
Frontiers in Molecular Neuroscience. 14 [DOI] 10.3389/fnmol.2021.747770. [PMID] 34630039.
Abrogation of atypical neurogenesis and vascular-derived EphA4 prevents repeated mild TBI-induced learning and memory impairments
Scientific Reports. 10(1) [DOI] 10.1038/s41598-020-72380-1. [PMID] 32958852.
Novel ablation methods for treatment of gliomas
Journal of Neuroscience Methods. 336 [DOI] 10.1016/j.jneumeth.2020.108630. [PMID] 32068011.
Lactobacillus rescues postnatal neurobehavioral and microglial dysfunction in a model of maternal microbiome dysbiosis.
Brain, behavior, and immunity. 81:617-629 [DOI] 10.1016/j.bbi.2019.07.025. [PMID] 31351186.
Peripheral loss of EphA4 ameliorates TBI-induced neuroinflammation and tissue damage
Journal of Neuroinflammation. 16(1) [DOI] 10.1186/s12974-019-1605-2. [PMID] 31711546.
Emergence of Neutrophil-Like Monocyte Subset with Distinct Single-Cell Transcriptomic Signature Controls Neuroinflammation in Brain Injury
. [DOI] 10.2139/ssrn.4319534.


Post doctoral associate, Laboratory of Neurotrauma and Repair.
2018-2023 · Virginia tech
Ph.D. in Biomedical and Veterinary Science
2018 · Virginia Tech
Doctor in Veterinary Medicine,
2010 · Universidad Austral de Chile

Contact Details

(352) 294-5064
Business Street:
1345 CENTER DR M548
Gainesville FL 32608