Erwin Kristobal Gudenschwager Basso

Erwin Kristobal Gudenschwager Basso,

Research Assistant Professor

Department: Department of Physiology and Aging
Business Phone: (352) 294-5064
Business Email: gudenschwagerwin@ufl.edu

About Erwin Kristobal Gudenschwager Basso

I am currently serving as a Research Assistant professor in the Department of Physiology and Aging, College of Medicine. My academic training began with the completion of my Doctor of Veterinary Medicine degree from Universidad Austral, Valdivia, Chile. Building upon my foundation in biomedical research, I pursued a Ph.D. in Biomedical and Veterinary Sciences at Virginia Tech, where I studied angiogenesis signaling in both placental development and skin tumors. Following my doctoral studies, I embarked upon a rewarding postdoctoral training focusing into the mechanisms underlying traumatic brain injury (TBI). My investigations utilized murine models of controlled cortical impact, repetitive mild TBI, and post-traumatic epilepsy (PTE). I sought to unravel the complexities of TBI and shed light on the role of the immune system in the aftermath of such injuries. The overarching objective of my research endeavors has been to identify strategies that mitigate secondary injury and promote enhanced recovery following TBI. I am also interested in unraveling the early brain changes that predispose individuals to the development of post-traumatic epilepsy. Furthermore, I am intrigued by the interplay between TBI and sleep disturbances, as well as the impact of TBI on circadian rhythms. Exploring these interconnected aspects will contribute to our understanding of the multifaceted nature of TBI and facilitate the development of novel therapeutic interventions. By virtue of my diverse academic background and research experience, I am committed to advancing the frontiers of knowledge in the field of traumatic brain injury and its associated sequelae. The opportunity to join the Department of Physiology and Aging at the University of Florida presents a unique platform for me to further explore these research avenues and make significant contributions to the scientific community.

Research Profile

https://orcid.org/0000-0001-7903-9992

Open Researcher and Contributor ID (ORCID)

0000-0001-7903-9992

Areas of Interest
  • Circadian Clock
  • Microglia
  • Neuroimmune interactions in Neurodegenerative diseases
  • Neuroimmunology
  • Stroke
  • traumatic brain injury

Publications

2023
A team science approach for the preclinical and clinical characterization and biomarker development for postā€traumatic epilepsy
Epilepsia Open. [DOI] 10.1002/epi4.12745.
2023
Atypical Neurogenesis, Astrogliosis, and Excessive Hilar Interneuron Loss Are Associated with the Development of Post-Traumatic Epilepsy
Cells. 12(9) [DOI] 10.3390/cells12091248. [PMID] 37174647.
2022
Characterization of the Expression of Angiogenic Factors in Cutaneous Squamous Cell Carcinoma of Domestic Cats
Veterinary Sciences. 9(7) [DOI] 10.3390/vetsci9070375. [PMID] 35878392.
2022
Monocyte proinflammatory phenotypic control by ephrin type A receptor 4 mediates neural tissue damage
JCI Insight. 7(15) [DOI] 10.1172/jci.insight.156319. [PMID] 35737458.
2022
Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury.
Frontiers in molecular neuroscience. 15 [DOI] 10.3389/fnmol.2022.852243. [PMID] 35283725.
2021
Conditional Deletion of EphA4 on Cx3cr1-Expressing Microglia Fails to Influence Histopathological Outcome and Blood Brain Barrier Disruption Following Brain Injury
Frontiers in Molecular Neuroscience. 14 [DOI] 10.3389/fnmol.2021.747770. [PMID] 34630039.
2020
Abrogation of atypical neurogenesis and vascular-derived EphA4 prevents repeated mild TBI-induced learning and memory impairments
Scientific Reports. 10(1) [DOI] 10.1038/s41598-020-72380-1. [PMID] 32958852.
2020
Novel ablation methods for treatment of gliomas
Journal of Neuroscience Methods. 336 [DOI] 10.1016/j.jneumeth.2020.108630. [PMID] 32068011.
2019
Lactobacillus rescues postnatal neurobehavioral and microglial dysfunction in a model of maternal microbiome dysbiosis.
Brain, behavior, and immunity. 81:617-629 [DOI] 10.1016/j.bbi.2019.07.025. [PMID] 31351186.
2019
Peripheral loss of EphA4 ameliorates TBI-induced neuroinflammation and tissue damage
Journal of Neuroinflammation. 16(1) [DOI] 10.1186/s12974-019-1605-2. [PMID] 31711546.
Emergence of Neutrophil-Like Monocyte Subset with Distinct Single-Cell Transcriptomic Signature Controls Neuroinflammation in Brain Injury
. [DOI] 10.2139/ssrn.4319534.

Education

Post doctoral associate, Laboratory of Neurotrauma and Repair.
2018-2023 · Virginia tech
Ph.D. in Biomedical and Veterinary Science
2018 · Virginia Tech
Doctor in Veterinary Medicine,
2010 · Universidad Austral de Chile

Contact Details

Phones:
Business:
(352) 294-5064
Emails:
Addresses:
Business Street:
1345 CENTER DR M548
Gainesville FL 32608