Hannah Costello

Hannah Costello,

Dr.

Department: Department of Physiology and Aging
Business Phone: 7500 781182
Business Email: hannahcostello@ufl.edu

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-9655-3798

Publications

2023
Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior.
Function (Oxford, England). 4(2) [DOI] 10.1093/function/zqad001. [PMID] 36778748.
2023
Circadian Disruption and the Molecular Clock in Atherosclerosis and Hypertension.
The Canadian journal of cardiology. 39(12):1757-1771 [DOI] 10.1016/j.cjca.2023.06.416. [PMID] 37355229.
2023
Defining the age-dependent and tissue-specific circadian transcriptome in male mice.
Cell reports. 42(1) [DOI] 10.1016/j.celrep.2022.111982. [PMID] 36640301.
2023
High salt intake activates the hypothalamic–pituitary–adrenal axis, amplifies the stress response, and alters tissue glucocorticoid exposure in mice
Cardiovascular Research. 119(8):1740-1750 [DOI] 10.1093/cvr/cvac160. [PMID] 36368681.
2023
Male kidney-specific BMAL1 knockout mice are protected from K+-deficient, high-salt diet-induced blood pressure increases.
American journal of physiology. Renal physiology. 325(5):F656-F668 [DOI] 10.1152/ajprenal.00126.2023. [PMID] 37706232.
2023
Palmitoylation of the pore-forming subunit of Ca(v)1.2 controls channel voltage sensitivity and calcium transients in cardiac myocytes
Proceedings of the National Academy of Sciences. 120(7) [DOI] 10.1073/pnas.2207887120. [PMID] 36745790.
2023
The circadian clock protein PER1 is important in maintaining endothelin axis regulation in Dahl salt-sensitive rats
Canadian Journal of Physiology and Pharmacology. 101(3):136-146 [DOI] 10.1139/cjpp-2022-0134. [PMID] 36450128.
2022
Circadian clocks of the kidney: function, mechanism, and regulation.
Physiological reviews. 102(4):1669-1701 [DOI] 10.1152/physrev.00045.2021. [PMID] 35575250.
2022
Kidney-specific KO of the circadian clock protein PER1 alters renal Na+ handling, aldosterone levels, and kidney/adrenal gene expression.
American journal of physiology. Renal physiology. 322(4):F449-F459 [DOI] 10.1152/ajprenal.00385.2021. [PMID] 35129370.
2022
Knockout of the Circadian Clock Protein PER1 (Period1) Exacerbates Hypertension and Increases Kidney Injury in Dahl Salt-Sensitive Rats.
Hypertension (Dallas, Tex. : 1979). 79(11):2519-2529 [DOI] 10.1161/HYPERTENSIONAHA.122.19316. [PMID] 36093781.
2022
The Seventeenth International Conference on Endothelin (ET-17)
Canadian Journal of Physiology and Pharmacology. 100(11):1028-1032 [DOI] 10.1139/cjpp-2022-0091. [PMID] 36169157.
2021
Activation of the Sympathetic Nervous System Promotes Blood Pressure Salt-Sensitivity in C57BL6/J Mice.
Hypertension (Dallas, Tex. : 1979). 77(1):158-168 [DOI] 10.1161/HYPERTENSIONAHA.120.16186. [PMID] 33190558.
2021
Circadian Rhythm Effects on the Molecular Regulation of Physiological Systems.
Comprehensive Physiology. 12(1):2769-2798 [DOI] 10.1002/cphy.c210011. [PMID] 34964116.
2021
Circadian Rhythm, Clock Genes, and Hypertension: Recent Advances in Hypertension.
Hypertension (Dallas, Tex. : 1979). 78(5):1185-1196 [DOI] 10.1161/HYPERTENSIONAHA.121.14519. [PMID] 34601963.
2019
A novel role for myeloid endothelin-B receptors in hypertension.
European heart journal. 40(9):768-784 [DOI] 10.1093/eurheartj/ehy881. [PMID] 30657897.
2019
Glucocorticoid receptor activation stimulates the sodium-chloride cotransporter and influences the diurnal rhythm of its phosphorylation.
American journal of physiology. Renal physiology. 317(6):F1536-F1548 [DOI] 10.1152/ajprenal.00372.2019. [PMID] 31588796.
2019
Impaired pressure natriuresis and non-dipping blood pressure in rats with early type 1 diabetes mellitus.
The Journal of physiology. 597(3):767-780 [DOI] 10.1113/JP277332. [PMID] 30537108.

Grants

Jan 2022 – Dec 2023
Contribution of the adrenal clock to renal function
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION

Education

Ph.D.
2017-2020 · University of Edinburgh
MSc
2016-2017 · University of Edinburgh
BSc with Honours
2012-2016 · University of Dundee

Contact Details

Phones:
Business:
7500 781182
Emails:
Addresses:
Business Mailing:
8 BAILIELANDS
LINLITHGOW FL EH497SU
Business Street:
Department of Physiology & Aging
1345 Center Drive
Gainesville FL 32610