Kit-Yan Cheng

Kit-Yan Cheng,

Medical Scientist II , University of Florida

Department: Department of Physiology and Aging
Business Email: isiaht@ufl.edu

About Kit-Yan Cheng

Additional Positions:
Medical Scientist II
2017 – Current · University of Florida
Biological Scientist
2007 – 2017 · University of Florida
Biological Laboratory Technician
2002 – 2007 · University of Florida

Publications

2023
Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior.
Function (Oxford, England). 4(2) [DOI] 10.1093/function/zqad001. [PMID] 36778748.
2023
Defining the age-dependent and tissue-specific circadian transcriptome in male mice.
Cell reports. 42(1) [DOI] 10.1016/j.celrep.2022.111982. [PMID] 36640301.
2023
Male kidney-specific BMAL1 knockout mice are protected from K+-deficient, high-salt diet-induced blood pressure increases.
American journal of physiology. Renal physiology. 325(5):F656-F668 [DOI] 10.1152/ajprenal.00126.2023. [PMID] 37706232.
2023
The circadian clock protein PER1 is important in maintaining endothelin axis regulation in Dahl salt-sensitive rats.
Canadian journal of physiology and pharmacology. 101(3):136-146 [DOI] 10.1139/cjpp-2022-0134. [PMID] 36450128.
2022
Apparent Absence of BMAL1-Dependent Skeletal Muscle-Kidney Cross Talk in Mice.
Biomolecules. 12(2) [DOI] 10.3390/biom12020261. [PMID] 35204763.
2022
Kidney-specific KO of the circadian clock protein PER1 alters renal Na+ handling, aldosterone levels, and kidney/adrenal gene expression.
American journal of physiology. Renal physiology. 322(4):F449-F459 [DOI] 10.1152/ajprenal.00385.2021. [PMID] 35129370.
2020
Differences in renal BMAL1 contribution to Na+ homeostasis and blood pressure control in male and female mice.
American journal of physiology. Renal physiology. 318(6):F1463-F1477 [DOI] 10.1152/ajprenal.00014.2020. [PMID] 32338037.
2020
Knockout of the circadian clock protein PER1 results in sex-dependent alterations of ET-1 production in mice in response to a high-salt diet plus mineralocorticoid treatment.
Canadian journal of physiology and pharmacology. 98(9):579-586 [DOI] 10.1139/cjpp-2019-0688. [PMID] 32437627.
2019
Direct and indirect inhibition of the circadian clock protein Per1: effects on ENaC and blood pressure.
American journal of physiology. Renal physiology. 316(5):F807-F813 [DOI] 10.1152/ajprenal.00408.2018. [PMID] 30759025.
2019
Female C57BL/6J mice lacking the circadian clock protein PER1 are protected from nondipping hypertension.
American journal of physiology. Regulatory, integrative and comparative physiology. 316(1):R50-R58 [DOI] 10.1152/ajpregu.00381.2017. [PMID] 30427705.
2018
Renal Na-handling defect associated with PER1-dependent nondipping hypertension in male mice.
American journal of physiology. Renal physiology. 314(6):F1138-F1144 [DOI] 10.1152/ajprenal.00546.2017. [PMID] 29357420.
2017
Desoxycorticosterone pivalate-salt treatment leads to non-dipping hypertension in Per1 knockout mice.
Acta physiologica (Oxford, England). 220(1):72-82 [DOI] 10.1111/apha.12804. [PMID] 27636900.
2015
Transcriptional regulation of NHE3 and SGLT1 by the circadian clock protein Per1 in proximal tubule cells.
American journal of physiology. Renal physiology. 309(11):F933-42 [DOI] 10.1152/ajprenal.00197.2014. [PMID] 26377793.
2014
A Role for the Circadian Clock Protein Per1 in the Regulation of Nhe3 and Sglt1 in Human Proximal Tubule Cells
The FASEB's Journal. 28(1, S)
2014
A role for the circadian clock protein Per1 in the regulation of the NaCl co-transporter (NCC) and the with-no-lysine kinase (WNK) cascade in mouse distal convoluted tubule cells.
The Journal of biological chemistry. 289(17):11791-11806 [DOI] 10.1074/jbc.M113.531095. [PMID] 24610784.
2014
Tissue-specific and time-dependent regulation of the endothelin axis by the circadian clock protein Per1.
Life sciences. 118(2):255-62 [DOI] 10.1016/j.lfs.2014.03.028. [PMID] 24721511.
2013
Mechanism of Per1 Action in Blood Pressure Control: Role of the Circadian Repressor Cry 2
The FASEB's Journal. 27
2013
Opposing actions of Per1 and Cry2 in the regulation of Per1 target gene expression in the liver and kidney.
American journal of physiology. Regulatory, integrative and comparative physiology. 305(7):R735-47 [DOI] 10.1152/ajpregu.00195.2013. [PMID] 23824961.
2013
Role of Per1 and the mineralocorticoid receptor in the coordinate regulation of αENaC in renal cortical collecting duct cells.
Frontiers in physiology. 4 [DOI] 10.3389/fphys.2013.00253. [PMID] 24062694.
2012
Inhibition of Alpha Enac Expression and Enac Activity Following Blockade of the Circadian Clock-Regulatory Kinases Cki Delta/Epsilon
The FASEB's Journal. 26
2012
Inhibition of αENaC expression and ENaC activity following blockade of the circadian clock-regulatory kinases CK1δ/ε.
American journal of physiology. Renal physiology. 303(7):F918-27 [DOI] 10.1152/ajprenal.00678.2011. [PMID] 22832921.
2012
Simultaneous introduction of a novel high fat diet and wheel running induces anorexia.
Physiology & behavior. 105(4):909-14 [DOI] 10.1016/j.physbeh.2011.11.011. [PMID] 22115947.
2012
The circadian protein period 1 contributes to blood pressure control and coordinately regulates renal sodium transport genes.
Hypertension (Dallas, Tex. : 1979). 59(6):1151-6 [DOI] 10.1161/HYPERTENSIONAHA.112.190892. [PMID] 22526258.
2011
POMC overexpression in the ventral tegmental area ameliorates dietary obesity.
The Journal of endocrinology. 210(2):199-207 [DOI] 10.1530/JOE-10-0418. [PMID] 21565854.
2011
Prevention and reversal of diet-induced leptin resistance with a sugar-free diet despite high fat content.
The British journal of nutrition. 106(3):390-7 [DOI] 10.1017/S000711451100033X. [PMID] 21418711.
2011
Simultaneous POMC gene transfer to hypothalamus and brainstem increases physical activity, lipolysis and reduces adult-onset obesity.
The European journal of neuroscience. 33(8):1541-50 [DOI] 10.1111/j.1460-9568.2011.07633.x. [PMID] 21366729.
2011
The act of voluntary wheel running reverses dietary hyperphagia and increases leptin signaling in ventral tegmental area of aged obese rats.
Gerontology. 57(4):335-42 [DOI] 10.1159/000321343. [PMID] 20881371.
2010
Pro-opiomelanocortin gene transfer to the nucleus of the solitary track but not arcuate nucleus ameliorates chronic diet-induced obesity.
Neuroscience. 169(4):1662-71 [DOI] 10.1016/j.neuroscience.2010.06.001. [PMID] 20538045.
2010
Regulation of αENaC expression by the circadian clock protein Period 1 in mpkCCD(c14) cells.
Biochimica et biophysica acta. 1799(9):622-9 [DOI] 10.1016/j.bbagrm.2010.09.003. [PMID] 20868778.
2008
Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding.
American journal of physiology. Regulatory, integrative and comparative physiology. 295(5):R1370-5 [DOI] 10.1152/ajpregu.00195.2008. [PMID] 18703413.
2008
Synergy between leptin therapy and a seemingly negligible amount of voluntary wheel running prevents progression of dietary obesity in leptin-resistant rats.
Diabetes. 57(3):614-22 [PMID] 18086903.
2007
Lean rats with hypothalamic pro-opiomelanocortin overexpression exhibit greater diet-induced obesity and impaired central melanocortin responsiveness.
Diabetologia. 50(7):1490-9 [PMID] 17505816.
2007
Leptin antagonist reveals an uncoupling between leptin receptor signal transducer and activator of transcription 3 signaling and metabolic responses with central leptin resistance.
The Journal of pharmacology and experimental therapeutics. 320(2):706-12 [PMID] 17082312.
2007
Melanocortin activation of nucleus of the solitary tract avoids anorectic tachyphylaxis and induces prolonged weight loss.
American journal of physiology. Endocrinology and metabolism. 293(1):E252-8 [PMID] 17389713.
2005
Leptin resistance exacerbates diet-induced obesity and is associated with diminished maximal leptin signalling capacity in rats.
Diabetologia. 48(6):1075-83 [PMID] 15864530.

Contact Details

Emails:
Business:
isiaht@ufl.edu
Addresses:
Business Mailing:
PO Box 100274
GAINESVILLE FL 32610