Colin Sumners, Ph.D.

Adjunct Professor

Colin Sumners, Ph.D.
Colin Sumners, Ph.D.

Phone: (352) 392-4485
Office: MBI L4-183


Education and Training/Previous Appointments

  • 1992-2017: Professor: Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL
  • 2005-17: Director: Junior Honors/Medical Honors Program, College of Medicine, University of Florida, Gainesville, FL
  • 1999-2010: Director: Medical Student Research Program, College of Medicine, University of Florida, Gainesville, FL
  • 1999-2001: Associate Dean for Graduate Education: College of Medicine, University of Florida, Gainesville, FL
  • 1987-92: Associate Professor (with tenure): Department of Physiology, University of Florida, Gainesville, FL
  • 1982-87: Assistant Professor: Department of Physiology, University of Florida, Gainesville, FL
  • 1981-82: Postdoctoral Associate: Department of Physiology, University of Florida, Gainesville, FL
  • 1979-80: Postdoctoral Fellow: Department of Pharmacy, University of Groningen, Holland
  • 1980: Ph.D.: University of Southampton, England (Physiology & Pharmacology)
  • 1976: B.Sc.: University of Southampton, England (Physiology & Biochemistry)

Research Interests

These fall within two areas:

  • Protective effects of brain Angiotensin type 2 receptors (AT2R)in neurogenic hypertension.
  • Cerebroprotective actions of AT2R and the receptor Mas in stroke.

Awards and Honors

  • Member of the McKnight Brain Institute
  • 2017: Lifetime Achievement Award, University of Florida College of Medicine
  • 2013-present: Fellow of the American Heart Association-Council for Hypertension
  • 2011: Exemplary Teacher, Five Year Award, University of Florida, College of Medicine
  • 2006-present: Alpha Omega Alpha Honor Medical Society, Beta Chapter, University of Florida
  • 2003-04, 2005-06, & 2008-09:Basic Science Teacher of the Year, University of Florida College of Medicine
  • 2003, 2006-10: Exemplary Teacher Award, University of Florida College of Medicine
  • 2002-05 & 2012-15: University of Florida Research Foundation (UFRF) Professorship
  • 1996-97: University of Florida Presidential Medal for University of Florida Teacher-Scholar of the Year
  • 1992-99: National Institutes of Health (NINDS), Javits Neuroscience Investigator MERIT Award
  • 1989-90: University of Florida Top 100 Researchers, President’s Research Achievement Award
  • 1979-80: Royal Society (London) European Program Postdoctoral Fellowship


PubMed Listing

  • Bennion, D. M., Steckelings, U. M., & Sumners, C. (2018). Neuroprotection via AT2 receptor agonists in ischemic stroke. Clinical science, 132(10), 1055-1067. doi: 10.1042/CS20171549. (PMID: 29802210)
  • Bennion, D. M., Jones, C. H., Donnangelo, L. L., Graham, J. T., Isenberg, J. D., Dang, A. N., Rodriguez, V., Sinisterra, R. D. M., Sousa, F. B., Santos, R. A. S., … Sumners, C. (2018). Neuroprotection by post-stroke administration of an oral formulation of angiotensin-(1-7) in ischaemic stroke. Experimental physiology, 103(6), 916-923. doi: 10.1113/EP086957. (PMID: 29663576)
  • Rathinasabapathy, A., Horowitz, A., Horton, K., Kumar, A., Gladson, S., Unger, T., Martinez, D., Bedse, G., West, J., Raizada, M. K., Steckelings, U. M., Sumners, C., Katovich, M. J., … Shenoy, V. (2018). The Selective Angiotensin II Type 2 Receptor Agonist, Compound 21, Attenuates the Progression of Lung Fibrosis and Pulmonary Hypertension in an Experimental Model of Bleomycin-Induced Lung Injury. Frontiers in physiology9, 180. doi:10.3389/fphys.2018.00180. (PMID: 29636695; PMCID: PMC5881224)
  • Peluso, A. A., Bertelsen, J. B., Andersen, K., Mortsensen, T. P., Hansen, P. B., Sumners, C., Bader, M., Santos, R. A., … Steckelings, U. M. (2018). Identification of protein phosphatase involvement in the AT2 receptor-induced activation of endothelial nitric oxide synthase. Clinical Science, 132(7), 777-790. doi: 10.1042/CS20171598. (PMID: 29540539)
  • Bennion, D. M., Jones, C. H., Dang, A. N., Isenberg, J., Graham, J. T., Lindblad, L., Domenig, O., Waters, M. F., Poglitsch, M., Sumners, C., … Steckelings, U. M. (2018). Protective effects of the angiotensin II AT2 receptor agonist compound 21 in ischemic stroke: a nose-to-brain delivery approach. Clinical Science, 132(5), 581-593. doi: 10.1042/CS20180100. (PMID: 29500223)
  • Steckelings, U. M., Kloet, A., & Sumners, C. (2017). Centrally Mediated Cardiovascular Actions of the Angiotensin II Type 2 Receptor. Trends in endocrinology and metabolism: TEM28(9), 684-693. (PMID: 28733135; PMCID: PMC5563271)
  • de Kloet, A. D., Steckelings, U. M., & Sumners, C. (2017). Protective Angiotensin Type 2 Receptors in the Brain and Hypertension. Current hypertension reports19(6), 46. (PMID: 28488048; PMCID: PMC5600899)
  • Bennion, D. M., Isenberg, J. D., Harmel, A. T., DeMars, K., Dang, A. N., Jones, C. H., Pignataro, M. E., Graham, J. T., Steckelings, U. M., Alexander, J. C., Febo, M., Krause, E. G., de Kloet, A. D., Candelario-Jalil, E., … Sumners, C. (2017). Post-stroke angiotensin II type 2 receptor activation provides long-term neuroprotection in aged rats. PloS one12(7), e0180738. doi:10.1371/journal.pone.0180738. (PMID: 28671997; PMCID: PMC5495490)
  • Hallberg, M., Sumners, C., Seckelings, U. M., & Hallberg, A. (2018). Small-molecule AT2 receptor agonists. Medicinal research reviews, 38(2), 602-624. doi: 10.1002/med.21449. (PMID: 28609561)
  • Bennion, D. M., Rosado, C. A., Haltigan, E. A., Regenhardt, R. W., Sumners, C., & Waters, M. F. (2016). Serum activity of angiotensin converting enzyme 2 is decreased in patients with acute ischemic stroke. Journal of the renin-angiotensin-aldosterone system : JRAAS17(3), 1470320316661060. doi:10.1177/1470320316661060. (PMID: 27488276; PMCID: PMC5843889)