Peter P. Sayeski, Ph.D.

Professor, Associate Chair, and Program Director

Sayeski Picture

Phone: (352) 392-1816
Office: MSB M560
Email: psayeski@ufl.edu

 

Education and Training/Previous Appointments

  • 2006-12: Associate Professor, Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL
  • 2000-06: Assistant Professor, Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL
  • 1996-2000: Post Doctoral Fellow: Emory University School of Medicine, Atlanta, GA (Pathology).
  • 1996: Ph.D.: The University of Alabama at Birmingham, Birmingham, AL (Physiology and Biophysics)
  • 1988: B.A.: The University of California at Berkeley, Berkeley, CA (Physiology-Anatomy)

Research Interests

The research in my laboratory is focused on better understanding the function of the tyrosine kinase, Jak2, and its role in human disease. Jak2 is expressed in nearly every tissue in the body. It is essential for life as animals lacking a functional Jak2 allele die during embryonic development. On the other hand, studies over the past decade have demonstrated that too much Jak2 kinase activity correlates with several human diseases including cardiovascular disease, diabetes and several types of cancer. Additionally, recent data has demonstrated that a specific Jak2 mutation, Jak2-V617F, is the cause of several types of blood disorders. Work in the lab is aimed at better understanding how Jak2 function is regulated within the cell and how we might be able to develop specific Jak2 inhibitors. Our hope is that we may one day be able to inhibit diseases that are caused by Jak2. A variety of cellular, molecular, genetic, biochemical and bio-informatic techniques are used for these studies.

Sayeski CV

Teaching (Including Courses)

  • Human Physiology in Translation (BMS 3521)
  • Aspects of the Art of Medicine (MDU 4008)
  • Principles of Physiology (GMS 6400C)
  • Medical Pulmonary Physiology (GMS 6402)
  • Fundamentals of Respiratory Physiology (GMS 6406)
  • The Respiratory System (BMS 6642)
  • The Cardiovascular System (BMS 6633)
  • Dental Physiology (DEN 5120C)

Awards and Honors

  • 2005-10, 2012-15, & 2017-18: Exemplary Teacher Award, University of Florida College of Medicine
  • 2015: Basic Science Teacher of the Year, University of Florida College of Medicine
  • 2012: Doctoral Dissertation Advisor/Mentoring Award, University of Florida
  • 2009: Doctoral Mentoring Award, University of Florida College of Medicine

Publications

PubMed Listing

  • Lee, E. J., Dykas, D. J., Leavitt, A. D., Camire, R. M., Ebberink, E., García de Frutos, P., Gnanasambandan, K., Gu, S. X., Huntington, J. A., Lentz, S. R., Mertens, K., Parish, C. R., Rezaie, A. R., Sayeski, P. P., Cromwell, C., Bar, N., Halene, S., Neparidze, N., Parker, T. L., Burns, A. J., Dumont, A., Yao, X., Chaar, C., Connors, J. M., Bale, A. E., … Lee, A. I. (2017). Whole-exome sequencing in evaluation of patients with venous thromboembolism. Blood advances1(16), 1224-1237. doi:10.1182/bloodadvances.2017005249. (PMID: 29296762; PMCID: PMC5728544)
  • Kiss, R., Bajusz, D., Baskin, R., Tóth, K., Monostory, K., Sayeski, P. P., & Keserű, G. M. (2016). Identification of 8-Hydroxyquinoline Derivatives Active Against Somatic V658F Mutant JAK1-Dependent Cells. Arch Pharm. 349(12), 925-933. doi: 10.1002/ardp.201600246. (PMID: 27862215)
  • Kobayashi, S. S., Vali, S., Kumar, A., Singh, N., Abbasi, T., & Sayeski, P. P. (2016). Identification of myeloproliferative neoplasm drug agents via predictive simulation modeling: assessing responsiveness with micro-environment derived cytokines. Oncotarget7(24), 35989-36001. (PMID: 27056884; PMCID: PMC5094977)
  • Klein, S., Rick, J., Lehmann, J., Schierwagen, R., Schierwagen, I. G., Verbeke, L., Hittatiya, K., Uschner, F. E., Manekeller, S., Strassburg, C. P., Wagner, K. U., Sayeski, P. P., Wolf, D., Laleman, W., Sauerbruch, T., … Trebicka, J. (2017). Janus-kinase-2 relates directly to portal hypertension and to complications in rodent and human cirrhosis. Gut, 66(1), 145-155. doi: 10.1136/gutjnl-2015-309600. (PMID: 26385087)
  • Baskin, R., Park, S. O., Keserű, G. M., Bisht, K. S., Wamsley, H. L., & Sayeski, P. P. (2014). The Jak2 small molecule inhibitor, G6, reduces the tumorigenic potential of T98G glioblastoma cells in vitro and in vivo. PloS one9(8), e105568. doi:10.1371/journal.pone.0105568. (PMID: 25162558; PMCID: PMC4146502)
  • Jin, X., Zhao, W., Kirabo, A., Park, S. O., Ho, W. T., Sayeski, P. P., & Zhao, Z. J. (2014). Elevated levels of mast cells are involved in pruritus associated with polycythemia vera in JAK2V617F transgenic mice. Journal of immunology, 193(2), 477-84. doi: 10.4049/jimmunol.1301946. (PMID: 24920845)
  • Sayeski, P. P. (2014). Hemodynamic regulator and mitogenic growth factor: re-visiting the age old question with ACE2 and Jak2. Regulatory Peptides, 189, v-vi. doi: 10.1016/j.regpep.2014.03.002. (PMID: 24631470)
  • Park, S. O., Wamsley, H. L., Bae, K., Hu, Z., Li, X., Choe, S. W., Slayton, W. B., Oh, S. P., Wagner, K. U., … Sayeski, P. P. (2013). Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans. PloS one8(3), e59675. (PMID: 23544085; PMCID: PMC3609865)
  • Kirabo, A., Park, S. O., Wamsley, H. L., Gali, M., Baskin, R., Reinhard, M. K., Zhao, Z. J., Bisht, K. S., Keserű, G. M., Cogle, C. R., … Sayeski, P. P. (2012). The small molecule inhibitor G6 significantly reduces bone marrow fibrosis and the mutant burden in a mouse model of Jak2-mediated myelofibrosis. The American journal of pathology181(3), 858-65. (PMID: 22796437; PMCID: PMC3432437)
  • Gnanasambandan, K., Magis, A. T., & Sayeski, P. P. (2012). A shift in the salt bridge interaction of residues D620 and E621 mediates the constitutive activation of Jak2-H538Q/K539L. Molecular and cell biochemistry, 367(1-2), 125-40. doi: 10.1007/s11010-012-1326-7. (PMID: 22584586)