Hideko Kasahara, M.D., Ph.D.

Associate Professor

Hideko Kasahara

Hideko Kasahara

Phone: (352) 846-1503
Office: MSB M543
Email: hkasahar@ufl.edu

 

Education and Training/Previous Appointments

  • 2002-09: Assistant Professor: Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL
  • 1998-2001: Instructor of Medicine: Harvard Medical School / Beth Israel Deaconess Medical Center, Boston, MA
  • 1997-98: Postdoctoral Fellow: Cardiovascular Division, Beth Israel Deaconess Medical Center / Harvard Medical School, Boston, MA
  • 1994-97: Postdoctoral Fellow: Department of Internal Medicine-Cardiology, Cardiovascular Research Center, University of Michigan, Ann Arbor, MI
  • 1991-94: National Institute for Physiological Sciences, Japan (Cell Biology)
  • 1994: Ph.D.: Nagoya University Medical School, Japan (Cardiology, Cell Biology)
  • 1985: M.D.:Nagoya University Medical School, Japan (Medicine)

Research Interests:

Our current research interest is to understand the function of Nkx2.5, an evolutionarily conserved NK2 class of homeobox transcription factor in mature cardiomyocytes.  Within the genomic analysis of cardiovascular diseases, mutations of NKX2.5 (capitals are used for human Nkx2.5) have emerged as a fascinating story both because of the roles this transcription factor plays in formation of the developing heart, as well as in maintenance of the normal heart after birth and through to adulthood.  We are particularly interested in a cardiac disorder in adults:  progressive AV block and left verntricular dysfunction caused by NKX2.5 mutations.  However, the current understanding of NKX2.5’s function is very limited in explaining how the molecular mechanisms of NKX2.5 mutations cause congenital heart disease.

Teaching (Including Courses)

  • Fundamentals of Medical Physiology (GMS 6440)
  • Fundamentals of Physiology and Functional Genomics 1 (GMS 6471)
  • Fundamentals of Physiology and Functional Genomics 2 (GMS 6472)
  • Human Physiology for Physician Assistants (PAS 5025)
  • Dental Physiology (DEN 5120C)

Awards and Honors

  • 2010-present: Appointment to Laboratory Investigation scientific journal
  • 2017 & 2018: Exemplary Teacher Award, University of Florida College of Medicine
  • 2016: Anderson Scholars Faculty Honoree, University of Florida
  • 2013: Research Administration Volunteer Recognition Award, American Heart Association Peer Review Committee
  • 2011: Top 5% reviewer in 2011, Editorial Board, Laboratory Investigation.
  • 2006: Abstract Travel Award, American Heart Association, Council on Basic Cardiovascular Sciences
  • 2000: Melvin L.Marcus Young Investigator Award (first prize), American Heart Association 73rd Scientific Sessions
  • 1998-2000: Post-Doctoral Research Fellowship (AHA-New England), 9820043T
  • 1996-1997: Post-Doctoral Research Fellowship (AHA-Michigan), 05RF967
  • 1995-1996: Post-Doctoral Research Fellowship (AHA-Michigan), 15F956

Publications

PubMed Listing

  • Calise, J., Abboud, G., Kasahara, H., Morel, L., & Chan, E.: Immune response-dependent assembly of IMP dehydrogenase filaments. Frontiers in Immunology, section T Cell Biology 2018. In press.
  • Moumne, O., Chowdhurry, R., Doll, C., Pereira, N., Hashimi, M., Grindrod, T., Dollar, J. J., Riva, A., … Kasahara, H. (2018). Mechanism Sharing Between Genetic and Gestational Hypoxia-Induced Cardiac Anomalies. Frontiers in cardiovascular medicine5, 100. doi:10.3389/fcvm.2018.00100. (PMID: 30151366; PMCID: PMC6099185)
  • Islam, Y. F., Joseph, R., Chowdhury, R. R., Anderson, R. H., & Kasahara, H. (2016). Heart Failure Induced by Perinatal Ablation of Cardiac Myosin Light Chain Kinase. Frontiers in physiology7, 480. doi:10.3389/fphys.2016.00480. (PMID: 27833563; PMCID: PMC5080352)
  • Massengill, M. T., Ashraf, H. M., Chowdhury, R. R., Chrzanowski, S. M., Kar, J., Warren, S. A., Walter, G. A., Zeng, H., Kang, B. H., Anderson, R. H., Moss, R. L., … Kasahara, H. (2016). Acute heart failure with cardiomyocyte atrophy induced in adult mice by ablation of cardiac myosin light chain kinase. Cardiovascular research111(1), 34-43. (PMID: 27025239; PMCID: PMC4909160)
  • Pradhan, L., Gopal, S., Li, S., Ashur, S., Suryanarayanan, S., Kasahara, H., & Nam, H. J. Intermolecular Interactions of Cardiac Transcription Factors NKX2.5 and TBX5. Biochemistry. 2016 Mar 29;55(12):1702-10. doi: 10.1021/acs.biochem.6b00171. (PMID: 26926761)
  • Bai, F., Ho Lim, C., Jia, J., Santostefano, K., Simmons, C., Kasahara, H., Wu, W., Terada, N., … Jin, S. (2015). Directed Differentiation of Embryonic Stem Cells Into Cardiomyocytes by Bacterial Injection of Defined Transcription Factors. Scientific reports5, 15014. doi:10.1038/srep15014. (PMID: 26449528; PMCID: PMC4598736)
  • Chowdhury, R., Ashraf, H., Melanson, M., Tanada, Y., Nguyen, M., Silberbach, M., Wakimoto, H., Benson, D. W., Anderson, R. H., … Kasahara, H. (2015). Mouse Model of Human Congenital Heart Disease: Progressive Atrioventricular Block Induced by a Heterozygous Nkx2-5 Homeodomain Missense Mutation. Circulation. Arrhythmia and electrophysiology8(5), 1255-64. (PMID: 26226998; PMCID: PMC4618020)
  • Cho, J., Seo, J., Lim, C. H., Yang, L., Shiratsuchi, T., Lee, M. H., Chowdhury, R. R., Kasahara, H., Kim, J. S., Oh, S. P., Lee, Y. J., … Terada, N. (2015). Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis. Cell death and differentiation22(9), 1437-50. (PMID: 25613378; PMCID: PMC4532771))
  • Liu, K., Lyu, L., Chin, D., Gao, J., Sun, X., Shang, F., Caceres, A., Chang, M. L., Rowan, S., Peng, J., Mathias, R., Kasahara, H., Jiang, S., … Taylor, A. (2015). Altered ubiquitin causes perturbed calcium homeostasis, hyperactivation of calpain, dysregulated differentiation, and cataract. Proceedings of the National Academy of Sciences of the United States of America112(4), 1071-6. (PMID: 25583491; PMCID: PMC4313858)
  • Ashraf, H., Pradhan, L., Chang, E. I., Terada, R., Ryan, N. J., Briggs, L. E., Chowdhury, R., Zárate, M. A., Sugi, Y., Nam, H. J., Benson, D. W., Anderson, R. H., … Kasahara, H. (2014). A mouse model of human congenital heart disease: high incidence of diverse cardiac anomalies and ventricular noncompaction produced by heterozygous Nkx2-5 homeodomain missense mutation. Circulation. Cardiovascular genetics7(4), 423-433. (PMID: 25028484; PMCID: PMC4140955)
  • Lee, K. Y., Li, M., Manchanda, M., Batra, R., Charizanis, K., Mohan, A., Warren, S. A., Chamberlain, C. M., Finn, D., Hong, H., Ashraf, H., Kasahara, H., Ranum, L. P., … Swanson, M. S. (2013). Compound loss of muscleblind-like function in myotonic dystrophy. EMBO molecular medicine5(12), 1887-900. (PMID: 24293317; PMCID: PMC3914532)