Heather Brockway, Ph.D.

Assistant Professor

Heather Brockway
Heather Brockway, Ph.D.

Phone: (352) 391-3791
Office: CG 20-F
Email: h.brockway@ufl.edu
NCBI Listing

Education and Training/Previous Appointments

  • 2014-20: Postdoctoral Training: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
  • 2014: Ph.D.: The University of Iowa, Iowa City, IA (Interdisciplinary Program in Genetics)
  • 2007: M.S.: Duquesne University, Pittsburgh, PA (Biological Sciences)
  • 2005: B.A.: University of Pittsburgh, Pittsburgh, PA (Anthropology)
  • 1997: B.S.: University of Pittsburgh, Pittsburgh, PA (Medical Sciences)

Research Interests

The placenta is first and most important organ all of us have had. Extra-embryonic in nature, it is key in the initiation, maintenance of, and ending of a pregnancy. As a cornerstone of the maternal-fetal interface, proper placental function is not only essential to a successful pregnancy, but fetal development which is essential to long term health. It is increasingly clear that adult disease can be traced back to in utero development and the role of the placenta as the supply route and barrier, providing nourishment and protection from transmission of maternal and external factors that would be detrimental to fetal development.

Dr. Brockway’s research encompasses various aspects of the maternal-fetal interface physiology underlying normal and adverse pregnancy outcomes. Of particular interest is the role of the placenta in normal birth timing and how placental hypermaturity impacts the maternal-fetal interface leading to premature birth. Current research topics include: using placental transcriptomics to identify essential biological pathways in placental maturation, deep phenotyping of idiopathic spontaneous birth to aberrant biological pathways related to birth timing, and the impact of pregnancy specific glycoproteins on pregnancy physiology.

Dr. Brockway utilizes multi-disciplinary approaches including but not limited to molecular, genomic, physiological, and computational techniques to examine the biological mechanisms of human placenta and interface physiology. The long-term goal of Dr. Brockway’s research is to build foundational and translational knowledge for future precision obstetrical/perinatal clinical care.

Teaching (Including Courses)

Awards and Honors

  • 2019: Perinatal Biology Symposium-NIH-USDA Travel Award
  • 2018: Women in Reproductive Sciences Post-Doc Appreciation Week Honoree
  • 2018: Perinatal Research Society Young Investigator Program/Grant Writing Workshop
  • 2018: Perinatal Research Society Mead Johnson Early Career Speaker
  • 2017-18: March of Dimes Interdisciplinary Scholar Award
  • 2017: International Federation of Placental Association, Manchester, UK – NIH Travel Award
  • 2013: University of Iowa Graduate College Summer Fellowship
  • 2010-12: University of Iowa Interdisciplinary Genetics Program Predoctoral Award from NIGMS Genetics Pre-doctoral Training Grant

Publications

NCBI Listing

  • Courtney, J., Troja, W., Owens, K. J., Brockway, H. M., Hinton, A. C., Hinton, R. B., Cnota, J. F., & Jones, H. N. (2020). Abnormalities of placental development and function are associated with the different fetal growth patterns of hypoplastic left heart syndrome and transposition of the great arteries. Placenta, 101, 57-65. doi: 10.1016/j.placenta.2020.09.007. Epub 2020 Sep 6. (PMID: 32927345)
  • Brockway, H. M., Kallapur, S. G., Buhimschi, I. A., Buhimschi, C. S., Ackerman, W. E., Muglia, L. J., & Jones, H. N. (2019). Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births. PLoS One, 14(11), e0225062. doi: 10.1371/journal.pone.0225062. eCollection 2019. (PMID: 31703110; PMCID: PMC6839872)
  • Paquette, A. G.*, Brockway, H. M.*, Price, N. D., & Muglia, L. J. (2018). Comparative transcriptomic analysis of human placentae at term and preterm delivery. Biol Reprod, 98(1), 89-101. doi: 10.1093/biolre/iox163. (PMID: 29228154; PubMed Central PMCID: PMC5803773) *co-first authors
  • Monangi, N. K., Brockway, H. M., House, M., Zhang, G., & Muglia, L. J. (2015). The genetics of preterm birth: Progress and promise. Semin Perinatol, 39(8), 574-83. doi: 10.1053/j.semperi.2015.09.005. Epub 2015 Oct 14. Review. (PMID: 26459968)
  • Brockway, H., Balukoff, N., Dean, M., Alleva, B., & Smolikove, S. (2014). The CSN/COP9 signalosome regulates synaptonemal complex assembly during meiotic prophase I of Caenorhabditis elegans. PLoS Genet, 10(11), e1004757. doi: 10.1371/journal.pgen.1004757. eCollection 2014 Nov. (PMID: 25375142; PMCID: PMC4222726)
  • Clemons, A. M., Brockway, H. M., Yin, Y., Kasinathan, B., Butterfield, Y. S., Jones, S. J., Colaiácovo, M. P., & Smolikove, S. (2013). akirin is required for diakinesis bivalent structure and synaptonemal complex disassembly at meiotic prophase I. Mol Biol Cell, 24(7), 1053-67. doi: 10.1091/mbc.E12-11-0841. Epub 2013 Jan 30. (PMID: 23363597; PMCID: PMC3608493)
  • Lin, L., Liu, S., Brockway, H., Seok, J., Jiang, P., Wong, W. H., & Xing, Y. (2009). Using high-density exon arrays to profile gene expression in closely related species. Nucleic Acids Res, 37(12), e90. doi: 10.1093/nar/gkp420. Epub 2009 May 27. (PMID: 19474342; PMCID: PMC2709591)
  • Conley, Y. P., Brockway, H., Beatty, M., & Kerr, M. E. (2003). Qualitative and quantitative detection of mitochondrial heteroplasmy in cerebrospinal fluid using denaturing high-performance liquid chromatography. Brain Res Brain Res Protoc, 12(2), 99-103. doi: 10.1016/j.brainresprot.2003.08.005. (PMID: 14613811)
  • Aungst, H., Ross, R., Brockway, H., Mesiano, S., & Muglia, L. *Can Evolution Inform Insights into Normal and Adverse Pregnancy Outcomes and Ultimately Improve Maternal and Fetal Care? In: Integrating Evolutionary Biology into Medical Education—for maternal and child healthcare students, clinicians, and scientists. Edited by: Jay Schulkin and Michael L. Power, Oxford University Press (2020). © Oxford University Press DOI:10.1093/oso/9780198814153.003.0006 *book chapter