Abdel Alli, PhD, MPH
Dr. Alli began his undergraduate studies at Valencia College and then graduated cum laude with a BS in Biology from the University of South Florida in 2003. He received an MPH in Global Health in 2004 and a PhD in Medical Sciences in 2009 from the University of South Florida. Dr. Alli completed his postdoctoral training in Physiology at Emory University in 2014. He completed a Fellowship in Research and Science Teaching at Emory University and was appointed to Assistant Professor in the Department of Physiology. Dr. Alli is now an Assistant Professor with a primary appointment in the Department of Physiology and Functional Genomics and a secondary appointment in the Department of Medicine at the University of Florida.
The long-term goal of Dr. Alli’s research program is to provide an understanding for the regulation of highly selective cation channels in diabetic nephropathy and in various blood pressure disorders, including hypertension. His current efforts are directed towards identifying the role of scaffolding proteins, kidney specific proteases, and exosomes in the regulation of these ion channels in health and disease.
Current projects in the Alli laboratory include (1) examining the role of scaffolding proteins (e.g. filamin, MARCKS, fodrin) in the phospholipid phosphate dependent regulation of membrane transporters in the kidney, (2) examining the role of exosomes in the regulation of sodium transport mechanisms in the nephron, and (3) identifying novel proteolytic dependent regulatory mechanisms in the kidney that regulate sodium transport.
The Alli laboratory applies a multidisciplinary approach that utilizes the full spectrum of molecular, biochemical, and physiological approaches in order to examine complex regulatory mechanisms of membrane transporters in both cellular and animal models. This allows for the identification of novel drug targets and the development of specific therapeutics.